基于因子分析和聚类分析的首发精神分裂症认知障碍亚型探究

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Abstract

Objective: Data-driven subtype grouping was conducted for cognitive impairment in the first-episode schizophrenia and subsequently explored the damage differences of independent cognitive dimensions in patients with different subtypes. Methods: The neurocognitive functions in 253 first-episode schizophrenia patients and 293 healthy controls were evaluated by the Cambridge Neuropsychological Test Automatic Battery (CANTAB). Then, different cognitive dimensions were extracted by factor analysis, and cluster analysis was carried out to group patients with first-episode schizophrenia. At the same time, psychopathological symptoms and the social professional function of the patient group were evaluated by the Positive Negative Syndrome(PANSS) and the Global Assessment Function(GAF) to explore the cognitive impairment mechanism and clinical characteristics of different cognitive subtypes. Results: The neurocognitive functions of the first-episode schizophrenia and the normal control could be divided into seven separable dimensions. Two hundred and fifty-three first-episode schizophrenics were divided into two subgroups: low-function group and high-function group. There were significant differences in cognitive function and clinical symptoms between different subgroups(P<0.01). Compared with the normal controls, the low-function group showed a more severe and extensive cognitive decline, while the highfunction group retained relatively inhibitory function, and the impairment of other cognitive dimensions was between the low-function group and the healthy controls. Conclusion: There are different cognitive subtypes of schizophrenia, and the impairment of inhibitory function is different in different subtypes of schizophrenia, which may be the core marker to identify different cognitive subtypes of first-episode schizophrenia.

Received: 30 April 2020

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	Articles by authors
	HU An-ran
	ZENG Jin-kun
	HE Tao
	YAO Xia
	DENG Wei

Cite this article:

HU An-ran,ZENG Jin-kun,HE Tao等.

Subtype identification of cognitive impairment in first-episode schizophrenia based on factor analysis and cluster analysis

[J]. Journal of Jiangsu University(Medicine Edition), 2020, 30(05): 445-450.

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2020/V30/I05/445

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