血清IL-33水平对动脉粥样硬化性脑梗死患者预后的预测价值

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Abstract [Abstract]Objective: To explore the prognostic value of serum IL33 in the prediction of the patients with atherosclerotic cerebral infarction (ACI). Methods: A total of 142 patients with ACI were enrolled. Their clinical data and National Institutes of Health Stroke Scale (NIHSS) were collected, and the serum IL33 level was detected by ELISA before treatment. Modified Rankin Scale (mRS) score was performed 90 days, and the patients were divided into the good prognosis group (n=69) and the poor prognosis group (n=73) according to mRS score. The general baseline data and serological data of the patients in the two groups were compared, respectively. The Spearman correlation between NIHSS score and IL33 level was analyzed, and Logistic regression was used to analyze the factors which influence the prognosis of the patients with ACI and the ROC curve of serum IL33 level was further plotted. Results: Age, past history of cerebral infarction and NIHSS score in poor prognosis group were higher than those in good prognosis group (P<0.05), and the serum IL33 level was significantly lower than those in good prognosis group (P<0.01). IL33 level was negatively correlated with the NIHSS score at admission(r=-0.581, P<0.01). Higher NIHSS score at admission was a risk factor for poor prognosis (P<0.01), while higher serum IL33 level was a protective factor (P<0.01). The ROC curve showed that the area under the curve was 0.835, the sensitivity was 91.3%, and the specificity was 72.5%. Conclusion: The decreased serum IL33 levels could be used as a predictor of poor prognosis for patients with ACI.

Received: 17 July 2019

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	Articles by authors
	WU Zheng-fu1
	HUANG Fei-ran2
	XU Yu-hao2
	YU Ming2

Cite this article:

WU Zheng-fu1,HUANG Fei-ran2,XU Yu-hao2等. Predictive value of serum interleukin-33 levels in the patients

with atherosclerotic cerebral infarction

[J]. Journal of Jiangsu University(Medicine Edition), 2020, 30(01): 72-74.

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2020/V30/I01/72

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［收稿日期］2019-06-21［编辑］刘星星

（上接第71页）

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