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Expression of Quaking isoform 7 in breast carcinoma and its relationship with prognosis of breast carcinoma patients |
XU Zhen-lei1, WANG Qing-wei2 |
(1. Department of Burn and Plastic Surgery, 2. Department of Laboratory Medicine, The Affiliated Huai′an No.1 People′s Hospital of Nanjing Medical University, Huai′an Jiangsu 223001, China)
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Abstract Objective: To investigate the expression of Quaking isoform 7(QKI-7) protein in breast carcinoma tissue and its clinical significance. Methods: The positive expression rate and intracellular localization of QKI-7 were detected in breast carcinoma and paracancerous tissues by immunohistochemical staining; correlation of QKI-7 expression with tumor tissues and clinical pathological parameters of patients, followup data, P53 and Ki67 expression were analyzed. Results: The positive rate of QKI-7 in breast carcinoma tissues was significantly lower than that in paracancerous tissues(χ2=73.378, P<0.05). The expression of QKI-7 in breast carcinoma tissue was related to tumor size, lymph node metastasis and TNM stage(all P<0.05). Cumulative survival rate in QKI-7 negative patients was significantly lower than that in QKI-7 positive patients(P<0.05); the expression of QKI7 in breast carcinoma tissue was positively correlated with P53 expression, while negatively correlated with Ki-67 expression(all P<0.05). Conclusion: The low expression of QKI7 may indicate poor prognosis of breast carcinoma patients.
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Received: 05 July 2018
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