|
|
Clinical significance of plasma D-dimer level in differentiating acute aortic dissection from non STsegment elevated acute coronary syndrome |
GUO Jun-fang, ZHANG Bao-wei, CHEN Rong, WANG Ying-ying, WANG Cheng-hua, TAO Ai-bin, BAO Zhong-hua, ZHANG Guo-hui, YIN Chun-yang |
(Department of Cardiology, the Affiliated People′s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002,China) |
|
|
Abstract Objective: To investigate the difference of plasma Ddimer levels between patients with acute aortic dissection (AAD) and ones with non STsegment elevated acute coronary syndrome (NSTACS), and the value of Ddimer was assessed in the differential diagnosis. Methods: This retrospective study collected data from 53 patients with AAD and 104 patients with NSTACS in the Chest Pain Center of the Affiliated People′s Hospital of Jiangsu University. Then the difference of plasma Ddimer was compared between patients with AAD and NSTACS. ROC curve was used to investigate the value of plasma Ddimer in the diagnosis of AAD. Results: Patients with AAD had higher levels of plasma Ddimer than patients with NSTACS (P<0.05). ROC curve showed plasma Ddimer level could be used to differentiate AAD from NSTACS (P<0.05). Conclusion: Patients with AAD had higher levels of plasma Ddimer than patients with NSTACS, and the Ddimer levels could be used to differentiate AAD from NSTACS.
|
Received: 21 December 2017
|
|
|
|
[1]Li W, Huang B, Tian L, et al. Admission Ddimer testing for differentiating acute aortic dissection from other causes of acute chest pain[J]. Arch Med Sci, 2017, 13(3): 591-596.[2]Roffi M, Patrono C, Collet JP, et al. 2015 ESC guideline for the management of acute coronary syndrome in patients presenting without persistent STsegment elevation:task force for the management of acute coronary syndrome in patients presenting without persistent STsegment elevation of European Sociaty of Cardiology[J]. Eur Heart J, 2016, 37(3):267-315.[3]Kline JA, Hogg MM, Courtney DM, et al. Ddimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography[J]. J Thromb Haemost, 2012, 10(4): 572-581.[4]Righini M, Van Es J, Den Exter PL, et al. Ageadjusted Ddimer cutoff levels to rule out pulmonary embolism: the ADJUSTPE study[J]. JAMA, 2014, 311(11): 111711-111724.[5]Pararella D, Rotunno C, Guida P, et al. Hemostasis alterations in patients with acute aortic dissection[J]. Ann Throac Surg, 2011, 91 (5): 1364-1369.[6]Sakamoto K, Yamamoto Y, Okamatsu H, et al. Ddimer is helpful for differentiating acute aortic dissection and acute pulmonary embolism from acute myocardial infarction[J]. Hellenic J Cardiol, 2011, 52(2): 123-127.[7]郭治国,马青变, 郑亚安,等.D二聚体在致命性胸痛病因诊断中的作用:附438例病例分析[J]. 中华急诊医学杂志,2013,25 (11): 655-659.[8]Hazui H, Fukumoto H, Negoro N, et al. Simple and useful tests for discriminating between acute aortic dissection of the ascending aorta and acute myocardial infarction in the emergency setting[J]. Circ J, 2005, 69 (6): 677-682.[9]Dong J, Duan X, Feng R, et al. Diagmostic implication of fibrin degradation products and Ddimer in aortic dissection[J]. Sci Rep, 2017, 7: 43957.[10]Olson JD. Ddimer: An overview of hemostasis and fibrinolysis, assays, and clinical applications[J]. Adv Clin Chem, 2015, 69: 1-46.[11]“D二聚体检测”急诊临床应用专家共识组. “D二聚体检测”急诊临床应用专家共识[J]. 中华急诊医学杂志, 2013, 22 (8): 827-836. |
[1] |
. [J]. Journal of Jiangsu University(Medicine Edition), 2012, 22(6): 549-550,552. |
|
|
|
|