强迫症初发患者纹状体区磁共振质子波谱治疗前后的变化

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Abstract Objective: To explore the abnormality of the brain′s metabolism about the bilateral corpus striatum in firstepisode obsessivecompulsive disorder patients receiving citalopram. Methods: Using magnetic resonance spectroscopy and analyzing technology1 HMRS to detect multiple metabolic indices of the corpus striatum of 20 patients receiving citalopram and 20 healthy persons, including NAA, Choline(Cho), myoinositol(MI), creatine(Cr). Results: The value NAA/Cr and Cho/Cr in the copus striatum of the firstepisode of obsessivecompulsive disorder group were significantly higher than those in the control group before treatment(P＜0.05),the value of MI/Cr was no significant change compared with that in the control group(P＞0.05); after treatment,the value of NAA/Cr was lower than before treatment(P＜0.05), the value of Cho/Cr and MI/Cr were no significant change(P＞0.05). Conclusion: 1 HMRS can provide some objective basis for clinical evaluation of the efficacy of OCD patients by measuring the changes of the metabolites in the striatum.

Received: 14 February 2017

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2017/V27/I02/154

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