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| Expression of NDRG-1，COX-2 and VEGF in cervical squamous cell carcinoma tissue and its clinical significance |
| YUAN Dong-lan1, QIAN Hua1, WANG Hua1, JIANG Jia-bao2, ZHU Xiao-wei3,JIAO Xia3, JIANG Xiao-qin3, XIAO Wei3, YU Hong3 |
| （1.Department of Gynaecology, 2.Department of General Surgery, 3.Department of Pathology, Taizhou People′s Hospital, Taizhou Jiangsu 225300, China) |
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Abstract Objective: To observe the expression of N-myc downstream regulated gene-1(NDRG-1), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in cervical squamous cell carcinoma tissue and to elucidate the mechanism of cervical squamous cell carcinoma invasion and metastasis. Methods: Expressions of NDRG-1, COX-2 and VEGF in tissue samples from 80 cervical squamous cell carcinoma cases and 15 healthy control cases were detected by immunohistochemistry; and their correlation with characteristics of clinical materials and prognosis in cervical squamous cell carcinoma were evaluated. Results: Compared with the normal cervical tissue, the positive expression rate of NDRG-1 in cervical squamous cell carcinoma tissue was significantly lower(P<0.01), while the positive rate of COX-2， VEGF was higher(both P<0.01).There was no significant difference between positive rate of NDRG-1,COX-2， VEGF expressions and clinicopathologic data of cervical squamous cell carcinoma patients including age and tumor size(P>0.05). Positive expression rate of NDRG-1, COX-2 and VEGF were significant correlated with tumor histopathological grade,clinical FIGO stages and lymph node metastasis(P<0.01).There was statistically significant positive correlation among NDRG-1,COX-2 and VEGF expressions in cervical squamous cell carcinoma tissue(P<0.01). There was statistically correlation between positive rate of NDRG-1,COX-2 and VEGF expression with survival time by KaplanMeier analysis. Conclusion: The abnormal expressions of NDRG-1,COX-2 ,VEGF might participate in the invasion and metastasis of cervical squamous cell carcinoma. The joint detection of NDRG-1, COX-2, VEGF might provide some guiding significance to judge the prognosis of cervical squamous cell carcinoma.
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2014, Vol. 24 
