|
|
|
| Relationships between CA19-9， CA24-2 levels and estradiol change in serum of normal female |
| AN Xian-yuan |
| (Department of Clinical Laboratory, Huadong Sanatorium, Wuxi Jiangsu 214065, China) |
|
|
|
|
Abstract Objective: To investigate the relationships between CA19-9 and CA24-2 levels and estradiol levels in the serum in female physiological periods. Methods: CA19-9 and CA24-2 and estradiol levels were detected in the serum in different physical period of 150 females, then the relationships between CA19-9 and CA24-2 levels and estradiol levels were analysed, and 150 males were used as controls. Results: The CA19-9 and CA24-2 levels in females serum were obviously higher than those of controls, respectively(t=4.848，P<0.001； t=8.11，P<0.001). The positive rate of CA199 and CA242 in females serum were also obviously higher than those of controls (χ2=6.621，P=0.010 1； χ2=8.219，P=0.004 1). There were obvious differences between the CA19-9 levels and CA24-2 levels in different physical period of females, respectively (F=10.53，P<0.001; F=12.61，P<0.001,). The CA19-9 levels and CA24-2 levels were negative correlations with that of estradiol levels in the serum of female, the equations were Y=－0.027 01X+38.62 (r2=0.523 9， P<0.001) and Y=－0.016 88X+ 23.40 (r2=0.653 1， P<0.001), respectively. Ten women with high CA19-9 and CA24-2 levels were followed up 5 years, the result showed that CA19-9 and CA242 levels almost decreased to normal after 6 months. Conclusion: The elevation of serum CA19-9 and CA24-2 levels in woman are not malignant and in connection with physical period of female.
|
|
Received: 24 May 2014
|
|
|
|
| [1]Magnani JL, Nilsson B, Brockhaus M, et al. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated Lacto-Nfucopentaose II\[J\]. J Biol Chem, 1982, 257(23):14365-14369.［2］Johansson C, Nisson O, Baeckstr-m D, et al. Novel epitopes on the CA50 carrying antigen: chemical and immunochemical studies\[J\]. Tumor Biol, 1991, 12（3）: 159-170.［3］Zhang D, Yu M, Xu T,et al. Predictive value of serum CEA, CA19-9 and CA125 in diagnosis of colorectal liver metastasis in Chinese population\[J\]. Hepatogastroenterology, 2013，60(126):1297-1301.［4］He CZ, Zhang KH, Li Q,et al. Combined use of AFP, CEA, CA125 and CA19-9 improves the sensitivity for the diagnosis of gastric cancer\[J\]. BMC Gastroenterol, 2013，13:87.［5］Tangkijvanich P, Thong-ngam D, Theamboonlers A, et al. Diagnostic role of serum interleukin 6 and CA19-9 in patients with cholangiocarcinoma\[J\]. Hepatogastroenterology, 2004, 51(55): 15-19.［6］Lelle RJ, Henkel E, Leinemann D,et al. Measurement of CEA, TPA, neopterin, CA125, CA153 and CA199 in sera of pregnant women, umbilical cord blood and amniotic fluid\[J\]. Gynecol Obstet Invest, 1989,27(3):137-142.［7］Hohla F, Hopfinger G, Romeder F, et al. Female gender may predict response to FOLFIRINOX in patients with unresectable pancreatic cancer: a single institution retrospective review\[J\].Int J Oncol, 2014，44(1):319-326.［8］Toki T , Kubota J ,Lu X, et al. Immunohistochemical analysis of CA125 ,CA199 and Ki67 in stage Ⅲor Ⅳendometriosis: positive correlation between serum CA125 level and endometriotic epithelial cell proliferation\[J\] . Acta Obsttet Gynecol Scad ,2000 ,79 (9) :771-776.［9］Nissenson AR ,Strobos J . Iron deficiency in patients with renal failure\[J\]. Kidney Int,1999,55 (Suppl) :S18-21.［10］Tong YL, Chen Y, Zhu SY. Ileocecal endometriosis and a diagnosis dilemma: a case report and literature review\[J\]. World J Gastroenterol, 2013，19(23):3707-3710. |
|
|
|
2014, Vol. 24 
