肺腺癌转移相关转录子-1和核因子-κB在食管鳞癌组织中的表达及其相关性

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Abstract Objective: To evaluate the expression and correlations of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1）， and NF-κB in the esophageal squamous cell carcinoma(ESCC) tissue. Methods: The expressions of MALAT-1 and NF-κB mRNA were detected by qRT-PCR in 60 ESCC tissues and adjacent non-tumorous tissues. The expression of NF-κB protein was detected by immunohistochemical staining (SP method), and the relationship between MALAT-1 and clinico-pathological feature of ESCC patients was analyzed, and the correlation was explored. Results: The expression of MALAT-1 and NF-κB both were higher in ESCC tissues than that in adjacent nontumorous tissues (Z=－3.600，P<0.001；Z=－2.856，P<0.05). The positive rate of NF-κB protein in ESCC tissues was significantly higher than that in adjacent nontumor tissues (χ2=36.39, P<0.001). Meanwhile, the higher expression of MALAT-1 and NF-κB were correlated with the differentiation degree, lymphnode metastasis and clinical stage of ESCC (P<0.05).And the expression of MALAT-1 and NF-κB was positive correlated (r=0.795，P<0.001). Conclusion: MALAT-1 might play a significant role in the occurrence and development of ESCC.

Received: 27 November 2013

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2014/V24/I02/129

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