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| Duration of proneposition ventilation influence the therapeutic effect on patients with early acute respiratory distress syndrome
caused by pulmonary diseases |
| YAN Jun， JI Mu-sen， JIN Zhao-chen |
| (Intensive Care Unit, Affiliated People′s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002， China) |
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Abstract Objective: To determine the efficacy of mechanical ventilation on prone position (PPV) on oxygenation and respiratory mechanics in patients with early acute respiratory distress syndrome (ARDS) resulting from pulmonary cause (ARDSp). Methods: Twenty-six ARDSp patients were placed in prone position for 6 h. The effect of different time (pre-PPV, PPV 0.5, 2, 4,6 h) on oxygenation and respiratory mechanics were observed. Results: Compared with pre-PPV, in ARDSp patients, partial pressure of oxygen in artery(PaO2)/ inhaled oxygen concentration (FiO2) was increased after 2 h PPV (224.86±30.84 vs 192.45±46.81, P=0.03). And 4 h after PPV, the PaO2/FiO2 still further raised compared with PPV 2 h (286.38±36.67 vs 224.86±30.84, P=0.00). No significant difference in the PaO2/FiO2 was found between PPV 4 h and PPV 6 h (286.38±36.67 vs 287.46±38.84, P=0.98). There was no significant difference in the respiratory system compliance between before and after the prone position ventilation(F=1.00, P=0.40). Conclusions: The PaO2/FiO2 was improved when patients with early ARDSp were ventilated on prone position, especially for 4 h PPV. ［Key words］ acute respiratory distress syndrome; prone position; oxygenation; respiratory mechanics
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| [1] |
YUAN Dong-Lan-1, Qian-Hua-1*, Wang-Hua-1, Jiang-Jia-Bao-2, Zhu-Xiao-Wei-3, Jiao-Xia-3, Jiang-Xiao-Qin-3, Xiao-Wei-3, Yu-Hong-3. Expression of NDRG-1，COX-2 and VEGF in cervical squamous cell carcinoma tissue and its clinical significance[J]. Journal of Jiangsu University(Medicine Edition), 2014, 24(3): 250-. |
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2013, Vol. 23 
