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| Expression of HSP27 and TGF-β1 in papillary thyroid carcinoma and its significance |
| CHEN Xia, YUAN Guo-yue, WANG Dong, WANG Ying, LI Mei |
| (Department of Endocrinology， the Affiliated Hospital of Jiangsu University， Zhenjiang Jiangsu 212001，China) |
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Abstract Objective: To investigate the expression and clinic significance of heat shock protein 27(HSP27) and TGF-β1 in papillary thyroid carcinoma. Methods: The expression of HSP27 and TGF-β1 was detected by immunohistochemistry in 50 cases with papillary thyroid carcinoma， 50 cases with thyroid adenoma and 30 cases with normal thyroid tissues，which had undergone operation in department of surgery，and confirmed by pathology. Results: The cells which express HSP27 and TGF-β1 were stained brown or dark brown in their cytoplasm.We choose the cells stained biopsy to detect. The positive expression rate of HSP27 was 70%(35/50) with papillary thyroid carcinoma，48%(24/50) with thyroid adenoma，46.7%(14/30) with normal thyroid tissues and of TGF-β1 was 80%(40/50) with papillary thyroid carcinoma， 62%(31/50) with thyroid adenoma，56.7%(17/30) with normal thyroid tissues.The positive rates of HSP27, TGF-β1 were significantly higher in the papillary thyroid carcinoma than in thyroid adenoma(P<0.05). The positive rates of HSP27, TGF-β1 were significantly higher in the papillary thyroid carcinoma than in normal thyroid tissues(P<0.05). The positive rates in the thyroid adenoma was close to the positive rates in normal thyroid tissues(P>0.05). Conclusion： The expression of HSP27 and TGFβ1 may be important biological markers reflecting the carcinogenesis, progression and prognosis of the papillary thyroid carcinoma. ［Key words］heat shock protein 27; transforming growth factorβ1; papillary thyroid carcinoma; thyroid adenoma
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2013, Vol. 23 
