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| Properties of molecularly imprinted polymers prepared with chondroitin sulfate based on nano-titanium dioxide |
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HUANG Qing1, XIA Sheng-yue2, GE Yan-ru1, QI Xue-yong1 |
| (1.School of Pharmacy, Jiangsu University, Zhenjiang Jiangsu 212013; 2.Hengxin Pharmaceutical Co., Ltd, Zhenjiang Jiangsu 212004, China) |
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Abstract Objective: To synthesize molecularly imprinted polymers(MIPs) for chondroitin sulfate(Chs) by using molecular imprinting technique(MIT) and study the biosorption of Chs onto Chs-MIPs. Methods: The MIPs with specific performances of recognition and adsorption towards to Chs were prepared in the presence of Chs as the template molecule, nano-titanium dioxide (TiO2) as the carrier and acrylamide (AM) as the functional monomer, the ethyleneglycol dimethacrylate(EGDMA) as the crosslinker, azodiisobutyronitrile as the initiator. The structure of Chs-MIPs was characterized by scanning electronic microscope(SEM). The synthesis conditions and the adsorption characteristics of Chs-MIPs were also studied. The fits of pseudo-first-order and pseduo-second-order were investigated to state the sorption kinetics. The Langmuir, Freundich were applied to model the biosorption equilibrium. Results: The optimum mass ratio between TiO2 and AM was 6∶1; the optimum molar ratio between EGDMA and AM was 7∶1. Compared with pseudo-first-order, pseudo-second-order kinetic model demonstrated a better correlation for the experimental data determined. Moreover, the Langmuir isothermal equation showed a good fit to the experimental data. Conclusion: The MIPs made by MIT presented better specific adsorption ability to Chs and durability performances, which were confirmed by repeated durability experiments. It might be used as an effective biosorbent to extract Chs from solution.
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Received: 13 February 2013
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2013, Vol. 23 
