类风湿关节炎患者外周血髓源性抑制细胞的检测及与Th1/Th2细胞的相关性分析

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Abstract Objective: To investigate the frequency of myeloid-derived suppressor cells(MDSCs) in the peripheral blood from patients with rheumatoid arthritis(RA) and assess the correlations between MDSCs and Th1/Th2 cells. Methods: A total of 36 RA patients were enrolled in the study. Disease activity was evaluated by calculating the 28-joint Disease Activity Score(DAS28) based on clinical information. RA patients were divided into active group and inactive group according to the DAS28 score. The frequency of MDSCs and Th1/Th2 cells in peripheral blood from RA patients and healthy controls were determined by flow cytometry. Results: The frequency of MDSCs increased significantly in active group compared with both inactive group and control group(P<0.05). However, there was no significant difference in the frequency of MDSCs between inactive group and control group(P>0.05). The frequency of MDSCs was negatively correlated with the frequency of Th1 cells in peripheral blood, but not correlated with the frequency of Th2 cells by Spearman′s test. Conclusion: The frequency of MDSCs in peripheral blood from RA patients is highly prevalent and closely related to helper T cells, which may become a valuable marker for the evaluation of RA.

Received: 28 January 2013

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2013/V23/I2/140

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