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| Expression and clinical significance of miR-146a in human esophageal squamous cell carcinoma |
| JIN Li-Yan-1, Chen De-Yu-2, Mao Chao-Ming-2 |
| 1.School of Clinical Medicine, Jiangsu University, Zhenjiang Jiangsu 212001; 2. Institute of Oncology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001，China |
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Abstract Objective: To investigate the expression of miR-146a in esophageal squamous cell carcinoma(ESCC) and analyze its correlation with clinicopathological features of ESCC. Methods: Stemloop RTPCR was used to detect the expression of miR-146a in 50 ESCC tissues and matched tumorfree tissues, and to analyze its correlation with clinicopathological features of ESCC. Results: The expression of miR-146a was significantly increased in ESCC tissues compared with the matched tumorfree tissues(Z=-3.162，P<0.01). Upregulation of miR-146a expression was correlated with differentiation degree, lymph node metastasis and clinical stage in ESCC(P<0.01). Conclusion: MiR-146a in ESCC tissues was significantly higher than that in matched tumorfree tissues, which may play a significant role in the occurrence and development of ESCC.
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Received: 25 June 2012
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2012, Vol. 22 
