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| Expression and clinical significance of ARHⅠ and DAPK in Human Glioma |
| HE Rui-1, 2 , Yuan Zhi-Cheng-1, Zhan Li-Ping-1, Li Qiao-Yu-1 |
| 1.Department of Neurosurgery， the Affiliated People′s Hospital, Jiangsu University，Zhenjiang Jiangsu 212002； 2.Clinical Medical College, Jiangsu University，Zhenjiang Jiangsu 212001,China |
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Abstract Objective: To investigate the expressions of aplysia ras homolog Ⅰ(ARHⅠ) and death associated protein kinase(DAPK) in normal brain tissues and glioma tissues and to analyse their clinical pathological significance. Methods: The SP immunohistochemical method was used to detect the expressions of ARHⅠ ans DAPK in 10 case of normal brain tissues and 47 case of human glioma samples. Results: The positive of ARHⅠ and DAPK were the highest in normal brain tissues.In glioma samples of different grades, the expression levels of ARHⅠ and DAPK decreased significantly with the increase of tumor malignancy. There was significant difference in the positive expression of ARHⅠ and DAPK between high grade and low grade glioma tissues.The difference was significant(P<0.05). The expression of ARHⅠ was correlated positively with the expression level of DAPK(r=0.723,P<0.05). Conclusion: The expression of ARHⅠ and DAPK were closely correlated with the clinical pathological grades. The downregulation of ARHⅠ and DAPK was involved in the initiation and progression of glioma.
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. [J]. Journal of Jiangsu University(Medicine Edition), 2018, 28(06): 546-. |
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2012, Vol. 22 
