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| Effects of the ethanol extractive of Borago officinalis on neurotransmitter in the brain tissue of mouse model of chronic depression |
| （Harbin Food and Drug Inspection Center， Harbin Heilongjiang 150525，China） |
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Abstract Objective: The effects of the extractive of Borago officinalis on norepinephrine（NE），dopamine and 5-hydroxytryptamine（5-HT）in mouse model of depression with chronic stress were investigated after establishing of chronic stress mouse models of depression; and to discuss its prevention and cure effects and their possible mechanisms. Methods: Established chronic stress mouse models of depression by using singly housed and long-trem unpredictable mild stress（CUMS）; and to determine the change of brain monoamine neurotransmitters of chronic stress depression model mice by using enzyme-linked immunosorbent assay（ELISA）. Results: The monoamine neurotransmitters（5-HT，NE，dopamine）contents in model mice were significantly less than normal group. The high，medium group of ethanol extractive from Borago officinalis all could increase the contents of 5-HT，NE，dopamine of mice with chronic stress depression;and the low group of ethanol extractive from Borago officinalis approached a raising trend，but no statistical significance. Conclusion: The Borago officinalis can elevate the contents of the 5-HT，NE and dopamine in the brian which were the possible mechanisms of the prevention and cure effect of the Borago officinalis.
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2012, Vol. 22 
