Abstract：Objective： To evaluate the efficacy of Leucogen in the treatment of influenza virus infection with neutropenia in children. Methods： Sixtythree cases of influenza virus infection combined with neutropenia in the Department of Pediatrics, Affiliated Hospital of Jiangsu University from January 2021 to January 2022 were collected. They were randomly divided into the observation group (33 cases) and the control group (30 cases). Eight serum respiratory pathogens, seven throat swab respiratory pathogens, blood routine examination, C-reactive protein, procalcitonin and blood culture were detected in the two groups. On the basis of routine treatment such as antiviral and symptomatic treatment, the observation group was given different doses of Leucogen orally according to ages. The changes of white blood cells and neutrophils were observed at different time points. Results： On the 5th day after treatment, white blood cells and neutrophils of the two groups were significantly higher than those before treatment (both P<0.01). When compared with the control group, the increase of white blood cells and neutrophils in the observation group was more significant after treatment with Leucogen (both P<0.05). When compared with the control group, the total effective rates of white blood cells and neutrophils elevation in the observation group were significantly different after treatment with Leucogen at 3 days, 5 days and 7 days (P<0.01). When compared with the control group, the obvious effect rates of white blood cells and neutrophils elevation were not significant at 3 days after Leucogen treatment, but the obvious effect rates of white blood cells and neutrophils elevation were statistically significant at 5 and 7 days (both P<0.05). Conclusion： After the treatment of influenza virus infection with neutropenia in children, Leucogen could obviously increase leukocytes and neutrophils, and may consequently shorten the window period of secondary bacterial infection.
刘欢， 王锁英， 李红. 利可君对流感病毒感染伴中性粒细胞减少患儿的疗效评估[J]. 江苏大学学报:医学版, 2023, 33(04): 333-337.
LIU Huan, WANG Suoying, LI Hong. Evaluation of the effect of Leucogen on neutropenia in children with influenza virus infection. Journal of Jiangsu University(Medicine Edition), 2023, 33(04): 333-337.
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