卒中后认知障碍患者粪便钙卫蛋白测定及其与血清炎性因子的相关性

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摘要目的：探讨卒中后认知障碍（post stroke cognitive impairment,PSCI）患者粪便钙卫蛋白（fecal calprotectin,FC）水平及其与认知状态和血清炎性因子的相关性。方法: 收集2021年3月至2022年3月就诊的PSCI患者32例、卒中后无认知障碍（post stroke with no cognitive impairment，PSNCI）患者44例和无卒中对照者25例，检测并对比3组中FC水平以及PSCI组治疗前后的FC水平。对PSCI组进行简易智力状态检查量表（minimental state examination，MMSE）和蒙特利尔认知评估量表（Montreal cognitive assessment，MoCA）评估，并检测血清C反应蛋白（CRP）和白介素6（IL6）的水平。结果: PSCI组、PSNCI组和对照组的年龄、性别、吸烟史、饮酒史未见明显差异，高血压史和糖尿病史在3组间存在显著差异（P<0.05），PSCI组FC水平显著高于PSNCI组和对照组（P<0.01）。对PSCI患者改善认知治疗1个月后，PSCI患者FC水平较治疗前显著降低（P<0.01）。在PSCI组中，FC水平与MoCA评分和MMSE评分呈负相关（P<0.01），与血清CRP水平和血清IL6水平呈正相关（P<0.01）。结论: PSCI患者FC水平升高，与PSCI患者的认知功能和血清炎性因子具有相关性，在PSCI的发生机制中发挥重要作用。

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	郭小燕
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Abstract：］Objective： To investigate the level of fecal calprotectin in patients with poststroke cognitive impairment (PSCI) and its correlation with cognition and serum inflammatory factors. Methods： Thirtytwo patients with PSCI, 44 patients with post stroke with no cognitive impairment (PSNCI) and 25 controls without stroke were enrolled from Mar 2021 to Mar 2022. The FC levels in the three groups were detected and compared, as well as before and after treatment in the PSCI group. Minimental state examination (MMSE) and Montreal cognitive assessment (MoCA) were performed in the PSCI group. The expressions of serum CRP and IL6 were also detected. Results： There were no significant differences in age, gender, smoking history and alcohol drinking history among the PSCI group, PSNCI group and control group, while there were significant differences in the history of hypertension and diabetes among the three groups (P<0.05). The level of FC in PSCI group was significantly higher than that in PSNCI and control group (P<0.05). After one month of cognitive therapy for PSCI patients, FC level of PSCI patients was significantly lower than that before treatment (P<0.01). In the PSCI group, FC level was negatively correlated with MoCA score and MMSE score (P<0.01), was positively correlated with serum CRP level and serum IL6 level (P<0.01). Conclusion： The increase of FC level in PSCI patients is correlated with cognitive function and serum inflammatory factors, which plays an important role in the pathogenesis of PSCI.

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收稿日期: 2022-09-15

基金资助: 国家自然科学基金资助项目（81871343）

通讯作者: 张利平（通讯作者），副主任医师，E-mail： 1289783340@qq.com

作者简介: 郭小燕（1992—），女，硕士研究生

引用本文:

郭小燕，李月峰，张利平.. 卒中后认知障碍患者粪便钙卫蛋白测定及其与血清炎性因子的相关性[J]. 江苏大学学报:医学版, 2023, 33(01): 63-66. GUO Xiaoyan1, LI Yuefeng2, ZHANG Liping1. Determination of fecal calprotectin and the correlation between fecal calprotectin and serum inflammatory factors in patients with post stroke cognitive impairment

. Journal of Jiangsu University(Medicine Edition), 2023, 33(01): 63-66.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2023/V33/I01/63

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