［2］Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants［J］. Chin Med J (Engl), 2022, 135(5): 584-590.

［3］Yates AG, Pink RC, Erdbrügger U, et al. In sickness and in health: the functional role of extracellular vesicles in physiology and pathology in vivo: Part Ⅱ: Pathology: Part Ⅱ: Pathology［J］. J Extracell Vesicles, 2022, 11(1): e12190.

［4］Cappello F, Fais S. Extracellular vesicles in cancer pros and cons: the importance of the evidencebased medicine［J］. Semin Cancer Biol, 2022, 86(Pt 1): 4-12.

［5］AraujoAbad S, Saceda M, de Juan Romero C. Biomedical application of small extracellular vesicles in cancer treatment［J］. Adv Drug Deliv Rev, 2022, 182: 114117.

［6］倪修凡, 张尤历, 徐岷. 外泌体源性长链非编码RNA在消化系统肿瘤中的研究进展［J］. 江苏大学学报（医学版）, 2020, 30(4): 293-297, 301.

［7］Wang S, Xu M, Li X, et al. Exosomes released by hepatocarcinoma cells endow adipocytes with tumorpromoting properties［J］. J Hematol Oncol, 2018, 11(1): 82.

［8］Fang JH, Zhang ZJ, Shang LR, et al. Hepatoma cellsecreted exosomal microRNA103 increases vascular permeability and promotes metastasis by targeting junction proteins［J］. Hepatology, 2018, 68(4): 1459-1475.

［9］Fang T, Lv H, Lv G, et al. Tumorderived exosomal miR12473p induces cancerassociated fibroblast activation to foster lung metastasis of liver cancer［J］. Nat Commun, 2018, 9(1): 191.

［10］Hu Y, Qi C, Liu X, et al. Malignant ascitesderived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer［J］. Cancer Lett, 2019, 457: 142-150.

［11］Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR133/PRDM16 pathway［J］. Int J Cancer, 2019, 144(10): 2501-2515.

［12］Li W, Zhang L, Guo B, et al. Exosomal FMR1AS1 facilitates maintaining cancer stemlike cell dynamic equilibrium via TLR7/NFκB/cMyc signaling in female esophageal carcinoma［J］. Mol Cancer, 2019, 18(1): 22.

［13］Zhang H, Deng T, Liu R, et al. CAF secreted miR522 suppresses ferroptosis and promotes acquired chemoresistance in gastric cancer［J］. Mol Cancer, 2020, 19(1): 43.

［14］Kang M, Ren M, Li Y, et al. Exosomemediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA［J］. J Exp Clin Cancer Res, 2018, 37(1): 171.

［15］Gwak HK, Lee JH, Park SG. Preliminary evaluation of clinical utility of CYFRA 211, CA 724, NSE, CA199 and CEA in stomach cancer［J］. Asian Pac J Cancer Prev, 2014, 15(12): 4933-4938.

［16］Hoshino A, Kim HS, Bojmar L, et al. Extracellular vesicle and particle biomarkers define multiple human cancers［J］. Cell, 2020, 182(4): 1044-1061.

［17］Jia Y, Yu L, Ma T, et al. Small extracellular vesicles isolation and separation: current techniques, pending questions and clinical applications［J］. Theranostics, 2022, 12(15): 6548-6575.

［18］Tanaka Y, Kamohara H, Kinoshita K, et al. Clinical impact of serum exosomal microRNA21 as a clinical biomarker in human esophageal squamous cell carcinoma［J］. Cancer, 2013, 119(6): 1159-1167.

［19］Luo A, Zhou X, Shi X, et al. Exosomederived miR3395p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma［J］. Oncogene, 2019, 38(25): 4990-5006.

［20］Fan L, Cao Q, Liu J, et al. Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis［J］. Mol Cancer, 2019, 18(1): 16.

［21］Li K, Lin Y, Luo Y, et al. A signature of salivaderived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study［J］. Mol Cancer, 2022, 21(1): 21.

［22］Li B, Xia Y, Lv J, et al. miR151a3prich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemnessenhancing niche［J］. Oncogene, 2021, 40(43): 6180-6194.

［23］Xin L, Zhou LQ, Liu C, et al. Transfer of LncRNA CRNDE in TAMderived exosomes is linked with cisplatin resistance in gastric cancer［J］. EMBO Rep, 2021, 22(12): e52124.

［24］Xie M, Yu T, Jing X, et al. Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR5823p/HUR/VEGF axis and suppressing HSP90 degradation［J］. Mol Cancer, 2020, 19(1): 112.

［25］Matsumura T, Sugimachi K, Iinuma H, et al. Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer［J］. Br J Cancer, 2015, 113(2): 275-281.

［26］Teng Y, Ren Y, Hu X, et al. MVPmediated exosomal sorting of miR193a promotes colon cancer progression［J］. Nat Commun, 2017, 8: 14448.

［27］Zheng R, Zhang K, Tan S, et al. Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3eIF3h interaction［J］. Mol Cancer, 2022, 21(1): 49.

［28］Sun B, Li Y, Zhou Y, et al. Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer［J］. J Cell Physiol, 2019, 234(2): 1416-1425.

［29］Soldevilla B, Rodríguez M, San Milln C, et al. Tumorderived exosomes are enriched in ΔNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival［J］. Hum Mol Genet, 2014, 23(2): 467-478.

［30］Lu JC, Zhang PF, Huang XY, et al. Amplification of spatially isolated adenosine pathway by tumormacrophage interaction induces antiPD1 resistance in hepatocellular carcinoma［J］. J Hematol Oncol, 2021, 14(1): 200.

［31］Nakamura K, Zhu Z, Roy S, et al. An exosomebased transcriptomic signature for noninvasive, early detection of patients with pancreatic ductal adenocarcinoma: a multicenter cohort study［J］. Gastroenterology, 2022, 163(5): 1252-1266.

［32］Xie Z, Gao Y, Ho C, et al. Exosomedelivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment［J］. Gut, 2022, 71(3): 568-579.

［33］Melo SA, Luecke LB, Kahlert C, et al. Glypican1 identifies cancer exosomes and detects early pancreatic cancer［J］. Nature, 2015, 523(7559): 177-182.

［34］Sun H, Wang C, Hu B, et al. Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3［J］. Signal Transduct Target Ther, 2021, 6(1): 187.

［35］Wang Z, Li Y, Mao R, et al. DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer［J］. Cell Death Dis, 2022, 13(2): 151.

［36］Li J, Li Y, Chen S, et al. Highly sensitive exosome detection for early diagnosis of pancreatic cancer using immunoassay based on hierarchical surfaceenhanced Raman scattering substrate［J］. Small Methods, 2022, 6(6): e2200154.

［37］Guo X, Lv X, Ru Y, et al. Circulating exosomal gastric cancerassociated long noncoding RNA1 as a biomarker for early detection and monitoring progression of gastric cancer: a multiphase study［J］. JAMA Surg, 2020, 155(7): 572-579.

［38］Roy S, Kanda M, Nomura S, et al. Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer［J］. Mol Cancer, 2022, 21(1): 42.

［39］Wang Y, Weng Q, Ge J, et al. tRNAderived small RNAs: mechanisms and potential roles in cancers［J］. Genes Dis, 2022, 9(6): 1431-1442.

［40］江佳佳, 吴佩佩, 许文荣. 肿瘤外泌体标志物应用及靶向治疗进展［J］. 江苏大学学报（医学版）, 2021, 31(1): 11-16.

［41］Xu J, Ji L, Liang Y, et al. CircRNASORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1［J］. Signal Transduct Target Ther, 2020, 5(1): 298.

［42］Zhou W, Zhou Y, Chen X, et al. Pancreatic cancertargeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment［J］. Biomaterials, 2021, 268: 120546.

［43］Xu L, Faruqu FN, LiamOr R, et al. Design of experiment (DoE)driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copperfree click chemistrybased labelling［J］. J Extracell Vesicles, 2020, 9(1): 1779458.

［44］Gong C, Zhang X, Shi M, et al. Tumor exosomes reprogrammed by low pH are efficient targeting vehicles for smart drug delivery and personalized therapy against their homologous tumor［J］. Adv Sci (Weinh), 2021, 8(10): 2002787.

［45］Lu Z, Zuo B, Jing R, et al. Dendritic cellderived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models［J］. J Hepatol, 2017, 67(4): 739-748.

［46］Yu Z, Lin S, Xia F, et al. ExoSD chips for highpurity immunomagnetic separation and highsensitivity detection of gastric cancer cellderived exosomes［J］. Biosens Bioelectron, 2021, 194: 113594.