氢溴酸山莨菪碱改善微循环障碍的机制研究进展

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摘要［摘要］氢溴酸山莨菪碱是从我国特产植物唐古特山莨菪中提取的一种天然生物碱，于1965年率先应用于临床，代号为6541。临床上常使用其人工合成替代品消旋山莨菪碱（654-2），改善微循环治疗感染性休克、平滑肌痉挛、有机磷农药中毒等。近年来，氢溴酸山莨菪碱的来源得到了有效保障，为了帮助氢溴酸山莨菪碱的临床应用开发及作用机制研究，本文对氢溴酸山莨菪碱在稳定细胞质膜、抗脂质过氧化、拮抗胆碱能受体、抗凝血与促纤溶、保护血管内皮糖萼和细胞间连接等方面的作用及其机制进行综述。

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	曾烨
	邱艳
	江文丽
	杜小强

关键词 ：氢溴酸山莨菪碱, 消旋山莨菪碱, 感染性休克, M胆碱受体, 微循环

收稿日期: 2020-12-02

基金资助:四川省重点研发项目（2021YFS0188）；四川大学横向理工医外协项目（19H0383）

作者简介: 曾烨（1984—），博士，副研究员，主要从事基础医学与生物医学工程学研究，E-mail：ye@scu.edu.cn

引用本文:

曾烨，邱艳，江文丽，杜小强. 氢溴酸山莨菪碱改善微循环障碍的机制研究进展[J]. 江苏大学学报:医学版, 2021, 31(01): 23-27.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2021/V31/I01/23

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