［1］Gwak HK, Lee JH, Park SG. Preliminary evaluation of clinical utility of CYFRA211, CA724, NSE, CA199 and CEA in stomach cancer\[J\]. Asian Pac J Cancer Prev, 2014, 15(12): 4933-4938.

［2］Kzhyshkowska J, Bizzarri M, Apte R, et al. Editorial:targeting of cancer cells and tumor microenvironment:perspectives for personalized therapy\[J\]. Curr Pharm Des, 2017, 23(32): 4703-4704.

［3］Rolfo C, Castiglia M, Hong D, et al. Liquid biopsies in lung cancer: the new ambrosia of researchers\[J\]. Biochim Biophys Acta, 2014, 1846(2):539-546.

［4］Li R, Jiang J, Shi H, et al. CircRNA: a rising star in gastric cancer\[J\]. Cell Mol Life Sci, 2020, 77(9):1661-1680.

［5］Jones L, Bell C, Bibb K, et al. Pathogens and their effect on exosome biogenesis and composition\[J\]. Biomedicines, 2018, 6(3):79.

［6］Hoshino A, Kim HS, Bojmar L, et al. Extracellular vesicle and particle biomarkers define multiple human cancers\[J\]. Cell, 2020, 182(4):1044-1061.

［7］Coumans FAW, Brisson AR, Buzas EI, et al. Methodological guidelines to study extracellular vesicles\[J\]. Circ Res, 2017, 120(10):1632-1648.

［8］Reid G, Kirschner MB, van Zandwijk N.Circulating microRNAs:association with disease and potential use as biomarkers\[J\]. Crit Rev Oncol Hematol, 2011, 80(2):193-208.

［9］Shi R, Wang PY, Li XY,et al. Exosomal levels of miRNA21 from cerebrospinal fluids associated with poor prognosis and tumor recurrenee of glioma patients\[J\]. Oncotarget, 2015, 6(29): 26971-26981.

［10］赵耀, 殷灵瑜, 毕茹茹, 等. 唾液外泌体的研究进展\[J\]. 中华口腔医学杂志, 2016, 51(12): 5-7.

［11］Li P, Kaslan M, Lee SH, et al. Progress in exosome isolation techniques\[J\]. Theranostics, 2017, 7(3):789-804.

［12］RomaRodrigues C, Fernandes AR, Baptista PV. Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells\[J\]. Biomed Res Int, 2014, 2014:179486.

［13］Melo SA, Luecke LB, Kahlert C, et al. Glypican1 identifies cancer exosomes and detects early pancreatic cancer\[J\]. Nature, 2015, 523(7559):177-182.

［14］Li J, Chen Y, Guo X, et al. GPC1 exosome and its regulatory miRNAs are specific markers for the detection and target therapy of colorectal cancer\[J\]. J Cell Mol Med, 2017, 21(5):838-847.

［15］Khan S, Jutzy JM, Valenzuela MM, et al. Plasmaderived exosomal survivin, a plausible biomarker for early detection of prostate cancer\[J\]. PLoS One, 2012, 7(10):e46737.

［16］Huang S, Xue P, Han X, et al. Exosomal miR130b3p targets SIK1 to inhibit medulloblastoma tumorigenesis\[J\]. Cell Death Dis, 2020, 11(6):408.

［17］Salehi M, Sharifi M. Exosomal miRNAs as novel cancer biomarkers:challenges and opportunities\[J\]. J Cell Physiol, 2018, 233(9):6370-6380.

［18］Armstrong DA, Green BB, Seigne JD, et al. MicroRNA molecular profiling from matched tumor and biofluids in bladder cancer\[J\]. Mol Cancer, 2015, 14:194.

［19］Liu Y, Luo F, Wang B, et al. STAT3regulated exosomal miR21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells\[J\]. Cancer Lett, 2016, 370(1):125-135.

［20］BautistaSánchez D, ArriagaCanon C, PedrozaTorres A, et al. The promising role of miR21 as a cancer biomarker and its importance in RNAbased therapeutics\[J\]. Mol Ther Nucleic Acids, 2020, 20:409-420.

［21］Tanaka Y, Kamohara H, Kinoshita K, et al. Clinical impact of serum exosomal microRNA21 as a clinical biomarker in human esophageal squamous cell carcinoma\[J\]. Cancer, 2013, 119(6):1159-1167.

［22］Samsonov R, Shtam T, Burdakov V, et al. Lectininduced agglutination method of urinary exosomes isolation followed by miRNA analysis: Application for prostate cancer diagnostic\[J\]. Prostate, 2016, 76(1):68-79.

［23］Xue XY, Liu YX, Wang C, et al. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma\[J\]. Signal Transduct Target Ther, 2020, 5(1) :77.

［24］倪修凡, 张尤历, 徐岷. 外泌体源性长链非编码RNA在消化系统肿瘤中的研究进展\[J\]. 江苏大学学报（医学版）, 2020, 30(4):293-297,301.

［25］Guo X, Lv X, Ru Y, et al. Circulating exosomal gastric cancerassociated long noncoding RNA1 as a biomarker for early detection and monitoring progression of gastric cancer:a multiphase study\[J\]. JAMA Surg,2020,155(7):572-579.

［26］Yao Z, Luo J, Hu K, et al. ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways\[J\]. Mol Oncol, 2017, 11(4):422.

［27］Tian G, Li G, Guan L, et al. Prognostic value of circular RNA ciRS7 in various cancers: a PRISMAcompliant metaanalysis\[J\]. Biomed Res Int, 2020, 2020:1-9.

［28］Li J, Li H, Lv X, et al. Diagnostic performance of circular RNAs in human cancers:a systematic review and metaanalysis\[J\]. Mol Genet Genomic Med, 2019, 7(7):e00749.

［29］Hu Y, Zhang R, Chen G. Exosome and secretion: action on? \[J\]. Adv Exp Med Biol, 2020, 1248:455-483.

［30］Chen G, Huang AC, Zhang W, et al. Exosomal PDL1 contributes to immunosuppression and is associated with antiPD1 response\[J\]. Nature, 2018, 560(7718):382-386.

［31］Demonbreun AR, McNally EM. Muscle cell communication in development and repair\[J\]. Curr Opin Pharmacol, 2017, 34:7-14.

［32］唐雨婷, 乔佳琦, 许文荣, 等. 外泌体在糖尿病及其并发症中的作用研究进展\[J\]. 江苏大学学报（医学版）, 2020, 30(4):298-301.

［33］Tran TH, Mattheolabakis G, Aldawsari H, et al. Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases\[J\]. Clin Immunol, 2015, 160(1):46-58.

［34］Chin AR, Fong MY, Somlo G, et al. Crosskingdom inhibition of breast cancer growth by plant miR159\[J\]. Cell Res, 2016, 26(2):217-228.

［35］Gao Y, Zhang H, Zhou N, et al. Methotrexateloaded tumourcellderived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma\[J\]. Nat Biomed Eng, 2020, 4(7):743-753.

［36］Geng X, Jia Y, Zhang Y, et al. Circular RNA: biogenesis, degradation, functions and potential roles in mediating resistance to anticarcinsuogens\[J\]. Epigenomics, 2019, 12(3):267-283.

［37］Gao Y, Li X, Zeng C, et al. CD63+ cancerassociated fibroblasts confer tamoxifen resistance to breast cancer cells through exosomal miR22\[J\]. Adv Sci (Weinh), 2020, 7(21):2002518.

［38］Uchihara T, Miyake K, Yonemura A, et al. Extracellular vesicles from cancerassociated fibroblasts containing annexin A6 induces FAKYAP activation by stabilizing β1 integrin, enhancing drug resistance \[J\]. Cancer Res, 2020, 80(16):3222-3235.

［39］Zimmer J, Hedlund M, Nagaeva O, et al. Thermal and oxidative stress causes enhanced release of NKG2D ligandbearing immunosuppressive exosomes in leukemia/lymphoma T and B Cells\[J\]. PLoS One, 2011, 6(2):e16899.

［40］Clayton A, Mitchell JP, Court J, et al. Human tumorderived exosomes selectively impair lymphocyte responses to interleukin2\[J\]. Cancer Res, 2007, 67(15):7458-7466.

［41］Filipazzi P, Bürdek M, Villa A, et al. Recent advances on the role of tumor exosomes in immunosuppression and disease progression\[J\]. Semin Cancer Biol, 2012, 22(4):342-349.

［42］Chalmin F, Ladoire S, Mignot G, et al. Membraneassociated Hsp72 from tumorderived exosomes mediates STAT3dependent immunosuppressive function of mouse and human myeloidderived suppressor cells\[J\]. J Clin Invest, 2010, 120(2):457-471.

［43］Zhang HG, Grizzle WE. Exosomes and cancer: a newly described pathway of immune suppression\[J\]. Clin Cancer Res, 2011, 17(5):959-964.

［44］Chen F, Chen J, Yang L, et al. Extracellular vesiclepackaged HIF1αstabilizing lncRNA from tumourassociated macrophages regulates aerobic glycolysis of breast cancer cells\[J\]. Nat Cell Biol, 2019, 21(4):498-510.

［45］Xie M, Yu T, Jing X, et al. Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR5823p/HUR/VEGF axis and suppressing HSP90 degradation\[J\]. Mol Cancer, 2020, 19(1) :112.

［46］Zhuang G, Wu X, Jiang Z, et al. Tumoursecreted miR9 promotes endothelial cell migration and angiogenesis by activating the JAKSTAT pathway\[J\]. EMBO J, 2012, 31(17): 3513-3523.

［47］Yang Y, Xiu F, Cai Z, et al. Increased induction of antitumor response by exosomes derived from interleukin2 genemodified tumor cells\[J\]. J Cancer Res Clin Oncol, 2007, 133(6):389-399.

［48］Webber J, Steadman R, Mason MD, et al. Cancer exosomes trigger fibroblast to myofibroblast differentiation\[J\]. Cancer Res, 2010, 70(23):9621-9630.

［49］Guo S, Chen J, Chen F, et al. Exosomes derived from Fusobacterium nucleatuminfected colorectal cancer cells facilitate tumour metastasis by selectively carrying miR1246/92b3p/27a3p and CXCL16\[J\].Gut,2020，69（11）: 321187.

［50］Clancy C, Joyce MR, Kerin MJ. The use of circulating microRNAs as diagnostic biomarkers in colorectal cancer\[J\]. Cancer Biomark, 2015, 15(2):103-113.

［51］DiazCano SJ. Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design \[J\]. Int J Mol Sci, 2012, 13(2):1951-2011.

［52］Schillaci O, Fontana S, Monteleone F, et al. Exosomes from metastatic cancer cells transfer amoeboid phenotype to nonmetastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity\[J\]. Sci Rep, 2017, 7(1): 4711.

［53］Sharma A. Chemoresistance in cancer cells: exosomes as potential regulators of therapeutic tumor heterogeneity\[J\]. Nanomedicine (Lond), 2017, 12(17):2137-2148.

［54］Baietti MF, Zhang Z, Mortier E,et al. SyndecansynteninALIX regulates the biogenesis of exosomes\[J\]. Nat Cell Biol, 2012, 14(7):677-685.