Abstract：Objective: To evaluate the effect of polyethylene glycol (PEG) electrolyte solution plus bisacodyl on the quality of bowel preparation in outpatients. Methods: Three hundred and sixty outpatients registered for colonoscopy were randomly divided into the experiment group (2 L PEG + 10 mg bisacodyl) and the control group (2 L PEG). The rate of adequate bowel preparation was assessed by the Boston bowel preparation scale (BBPS) and adenoma detection rate, cecal intubation rate and adverse reaction rate in two groups were analysed. Results: The rate of adequate bowel preparation in the experimental group (91.1%) was significantly higher than that in the control group (77.2%, χ2=13.028, P0.05). Conclusion: PEG(2 L) combined with 10 mg bisacodyl may significantly improve the quality of bowel preparation in outpatients and increase the adenoma detection rate, without increasing the risk of adverse reactions.
孙文荣， 叶院宁， 施慧， 陆恒， 汪芳裕. 复方聚乙二醇电解质溶液联合比沙可啶对门诊患者肠道准备质量的影响[J]. 江苏大学学报:医学版, 2018, 28(05): 403-406.
SUN Wen-rong, YE Yuan-ning, SHI Hui, LU Heng, WANG Fang-yu. Effect of polyethylene glycol electrolyte solution plus bisacodyl on
the quality of bowel preparation in outpatients. Journal of Jiangsu University(Medicine Edition), 2018, 28(05): 403-406.
［1］中华人民共和国卫生和计划生育委员会医政医管局，中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2017年版)\[J\]. 中华外科杂志,2018，56(4):241-258.［2］Hassan C, Bretthauer M, Kaminski MF, et al. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline\[J\]. Endoscopy, 2013, 45(2):142-150.［3］Johnson DA, Barkun AN, Cohen LB, et al. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multisociety task force on colorectal cancer\[J\]. Gastroenterology, 2014, 147(4):903-924.［4］ASGE Standards of Practice Committee, Saltzman JR, Cash BD, et al. Bowel preparation before colonoscopy\[J\]. Gastrointest Endosc, 2015, 81(4):781-794.［5］中华医学会消化内镜学分会. 中国消化内镜诊疗相关肠道准备指南(草案)\[J\]. 中国实用内科杂志,2013,33(9):705-707.［6］Xie Q, Chen L, Zhao F, et al. A metaanalysis of randomized controlled trials of lowvolume polyethylene glycol plus ascorbic acid versus standardvolume polyethylene glycol solution as bowel preparations for colonoscopy\[J\]. PLoS One, 2014, 9(6):e99092.［7］Jin Z, Lu Y, Zhou Y, et al. Systematic review and metaanalysis: sodium picosulfate/magnesium citrate vs. polyethylene glycol for colonoscopy preparation\[J\]. Eur J Clin Pharmacol, 2016, 72(5):523-532.［8］Zorzi M, Valiante F, German B, et al. Comparison between different colon cleansing products for screening colonoscopy. A noninferiority trial in populationbased screening programs in Italy\[J\]. Endoscopy, 2016, 48(3):223-231.［9］Zhang S, Zheng D, Wang J, et al. Simethicone improves bowel cleansing with lowvolume polyethylene glycol: a multicenter randomized trial\[J\]. Endoscopy, 2018, 50(4): 412-422.［10］Zhang S, Li M, Zhao Y, et al. 3L splitdose is superior to 2L polyethylene glycol in bowel cleansing in Chinese population: a multicenter randomized, controlled trial\[J\]. Medicine (Baltimore), 2015, 94(4):e472.［11］Lai EJ, Calderwood AH, Doros G, et al. The Boston bowel preparation scale: a valid and reliable instrument for colonoscopyoriented research\[J\]. Gastrointest Endosc, 2009, 69(3 Pt 2): 620-625.［12］Kim HG, Huh KC, Koo HS, et al. Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: a multicenter randomized singleblinded trial\[J\]. Gut Liver, 2015, 9(4): 494-501.［13］Gerard DP, Holden JL, Foster DB, et al. Randomized trial of Gatorade/polyethylene glycol with or without bisacodyl and NuLYTELY for colonoscopy preparation\[J\]. Clin Transl Gastroenterol,2012,3(6):e16.［14］Li Y, Jia X, Liu B, et al. Randomized controlled trial: Standard versus supplemental bowel preparation in patients with Bristol stool form 1 and 2\[J\]. PLoS One,2017,12(2):e171563.［15］Kang X, Zhao L, Zhu Z, et al. Sameday single dose of 2 liter polyethylene glycol is not inferior to the standard bowel preparation regimen in lowrisk patients: a randomized, controlled trial\[J\]. Am J Gastroenterol,2018,113(4):601-610.［16］Ajani S, Hurt RT, Teeters DA, et al. Ischaemic colitis associated with oral contraceptive and bisacodyl use\[J\]. BMJ Case Rep, 2012, 2012:bcr1220115451.［17］Dik VK, Moons LM, Hüyük M, et al. Predicting inadequate bowel preparation for colonoscopy in participants receiving splitdose bowel preparation: development and validation of a prediction score\[J\]. Gastrointest Endosc, 2015, 81(3):665-672.［18］方军，马丹，王树玲，等. 肠道准备质量影响因素中患者相关因素的研究进展\[J\]. 中华消化内镜杂志,2016,33(4):265-267.
2018, Vol. 28 
