Abstract：［Abstract］Objective： To investigate the change and potential significance of follicular regulatory T cells (Tfr) percentage in murine model of Lewis lung carcinoma mice. Methods： The mice were injected with the Lewis cells to establish murine model of lung carcinoma. The percentage of Tfr cells and CD4+CXCR5+T cells in abdominal drainage lymph nodes and tumor tissues were determined by flow cytometer．The change at ratio of Tfr/CD4+CXCR5+T cell were analyzed. Results： Compared with the normal control mice (1.97±0.26)%,tumorburdened mice (4.13±0.35)% had a significantly higher percentage of Tfr cells in abdominal drainage lymph nodes(t=4.985, P<0.01). Tfr/CD4+CXCR5+T cell ratio in tumorburdened mice(0.39±0.03) was also obviously increased(t=5.148, P<0.01) compared with the normal control mice(0.21±0.02). The percentage of Tfr cells in tumor tissues had a significantly higher on fourteenth day,the difference was statistically significant compared with seventh days(t=5.617, P<0.01). Conclusion： The increased percentage of Tfr cells in Lewis lung carcinoma mice and the imbalance of Tfr/CD4+CXCR5+T cell ratio indicated that Tfr cells may be involved in the progression of lung carcinoma.
冯玎琦， 汤新逸， 张悦， 马洁， 田洁， 许化溪， 王胜军. 滤泡调节性T细胞在肺癌移植瘤小鼠体内的变化及意义[J]. 江苏大学学报:医学版, 2016, 26(04): 288-291.
FENG Ding-qi, TANG Xin-yi, ZHANG Yue, MA Jie, TIAN Jie, XU Hua-xi, WANG Sheng-jun. Increasement and significance of follicular regulatory T cells in the murine model of Lewis lung carcinoma. Journal of Jiangsu University(Medicine Edition), 2016, 26(04): 288-291.
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2016, Vol. 26 
