血清小而密低密度脂蛋白胆固醇和总抗氧化能力水平与脑梗死患者认知功能障碍的相关性分析

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摘要目的：探究脑梗死患者血清小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein cholesterol，sdLDL-C)和总抗氧化能力(total antioxidant capacity，T-AOC)水平变化及其与认知功能障碍发生的关系。方法：选择148例脑梗死患者，依据发病后7 d是否出现认知功能障碍，分为非障碍组(n=77)和障碍组(n=71)；分别采用过氧化氢酶法和比色法测定两组血清sdLDL-C和T-AOC水平，并进行比较；Pearson相关系数法分析脑梗死患者血清sdLDL-C、T-AOC水平与蒙特利尔认知评估(MoCA)评分相关性；二元Logistic回归分析影响脑梗死患者认知功能障碍发生的危险因素。结果：与非障碍组相比，障碍组血清sdLDL-C水平明显升高(P＜0.05)，T-AOC水平明显降低(P＜0.05)。相关性分析显示，血清sdLDL-C水平与MoCA评分呈负相关(r=-0.516，P＜0.05)，T-AOC水平与MoCA评分呈正相关(r=0.446，P＜0.05)。Logistic回归分析显示，高血压、糖尿病、病情严重程度、血清sdLDL-C和T-AOC是脑梗死患者认知功能障碍发生的独立影响因素(P＜0.05)。结论：脑梗死患者血清sdLDL-C水平升高，T-AOC水平降低，二者是影响脑梗死患者并发认知功能障碍的独立影响因素。

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	马娟
	郝晨光
	何丹
	马建华

关键词 ：脑梗死font-family: ????, font-weight: 700, text-align: -webkit-right, ')" href="#">background-color: rgb(212, 226, 255);">, 认知功能障碍font-family: ????, font-weight: 700, text-align: -webkit-right, ')" href="#">background-color: rgb(212, 226, 255);">, 小而密低密度脂蛋白胆固醇font-family: ????, font-weight: 700, text-align: -webkit-right, ')" href="#">background-color: rgb(212, 226, 255);">, 总抗氧化能力

Abstract： Objective： To investigate the serum small dense low-density lipoprotein cholesterol (sdLDL-C) and total antioxidant capacity (T-AOC) in patients with cerebral infarction and its relationship with cognitive dysfunction. Methods： A total of 148 patients with cerebral infarction were selected and divided into non-impaired group (n=77) and impaired group (n=71) according to whether cognitive dysfunction occurred 7 days after onset. The levels of serum sdLDL-C and T-AOC in the two groups were determined by hydroperoxidase and colorimetry, respectively, and compared. The correlation between serum sdLDL-C, T-AOC and Montreal Cognitive Assessment (MoCA) score in patients with cerebral infarction was analyzed by Pearson correlation coefficient method. The risk factors of cognitive dysfunction in patients with cerebral infarction were analyzed by binary Logistic regression. Results： Compared with the non-impaired group, the serum sdLDL-C level in the impaired group was significantly increased (P<0.05), and the T-AOC level was greatly decreased (P<0.05). Correlation analysis showed that serum sdLDL-C level was negatively correlated with MoCA score (r=-0.516, P<0.05), while T-AOC level was positively correlated with MoCA score (r=0.446, P<0.05). Logistic regression analysis showed that hypertension, diabetes, disease severity, serum sdLDL-C and T-AOC were independent factors affecting the occurrence of cognitive dysfunction in patients with cerebral infarction (P<0.05). Conclusion： The level of serum sdLDL-C is increased and the level of T-AOC is decreased in patients with cerebral infarction, which are independent influencing factors for cognitive dysfunction in patients with cerebral infarction.

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收稿日期: 2023-01-10

基金资助: 新疆维吾尔自治区自然科学基金资助项目(2017D01A05)

通讯作者: 马建华(通讯作者)，主任医师，E-mail: mjh9191@163.com

作者简介: 马娟(1988—)，女，硕士，主治医师，主要从事脑血管病等研究

引用本文:

马娟，郝晨光，何丹，马建华. 血清小而密低密度脂蛋白胆固醇和总抗氧化能力水平与脑梗死患者认知功能障碍的相关性分析[J]. 江苏大学学报:医学版, 2024, 34(02): 161-165,175. MA Juan, HAO Chenguang, HE Dan, MA Jianhua. Correlation analysis of serum levels of small dense low-density lipoprotein cholesterol and total antioxidant capacity with cognitive dysfunction in patients with cerebral infarction. Journal of Jiangsu University(Medicine Edition), 2024, 34(02): 161-165,175.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2024/V34/I02/161

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