双硫死亡及其与肿瘤关系的研究进展

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摘要硫元素主要存在于L半胱氨酸和L甲硫氨酸两种含硫氨基酸中。硫在维持氧化还原稳态或在抗氧化防御系统中发挥重要作用。2023年2月甘波谊团队在Nature Cell Biology杂志首次报道了一种新的细胞死亡方式，即在葡萄糖饥饿状态下，癌细胞中胱氨酸转运体溶质载体家族7成员11(solute carrier family 7 member 11，SLC7A11)高表达致二硫化物(如胱氨酸等)异常积累，并伴随着NADPH耗尽，最终导致癌细胞死亡。因此种死亡方式具有二硫化物应激的特点，故命名为“双硫死亡”(disulfidptosis)。本文针对双硫死亡的发现过程、双硫应激、硫代谢及双硫死亡与肿瘤的关系进行综述。

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	王燕青1
	杨林1
	成春锋1
	陈东风2
	冼绍祥3
	方红城1

关键词 ：双硫死亡, 双硫应激, 半胱氨酸, 溶质载体家族7成员11(SLC7A11, 胱氨酸转运体

收稿日期: 2023-05-08

基金资助:国家自然科学基金资助项目（82174316）；广东省基础与应用基础研究基金资助项目(2023A1515010282)；深圳市“医疗卫生三名工程项目”(SZZYSM202106006)

通讯作者: 方红城(通讯作者)，主任医师，博士生导师，E-mail： 13602568079@139.com

作者简介: 王燕青(1992—)，女，2022级中西医结合基础博士研究生；

引用本文:

王燕青1，杨林1，成春锋1，陈东风2，冼绍祥3，方红城1. 双硫死亡及其与肿瘤关系的研究进展[J]. 江苏大学学报:医学版, 2023, 33(05): 391-397.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2023/V33/I05/391

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