Abstract：Objective: To assess the effect of oxycodone combined with levobupivacaine on epidural analgesia for labor. Methods: A total of 84 parturients who were to receive epidural labor analgesia were divided into two groups randomly, with 42 patients in each group. The Group oxycodone received 0.1% levobupivacaine with 0.2 mg/mL oxycodone, and the Group fentanil received 0.1% levobupivacaine with 2 μg/mL fentanil for epidural labor analgesia. The visual analogue scale/score(VAS), Bromage score, the onset time of analgesia, the first time of patientcontrolled epidural analgesia(PCEA), labor duration, delivery mode, adverse reactions, Apgar score and umbilical cord blood gas analysis at each time point were observed. Results: The VAS at each time point in the two groups was lower than that before analgesia (P<0.05). There was no significant difference in the analgesia score at each time point between the two groups. The onset time of analgesia was shorter in Group oxycodone than that in Group fentanil (P<0.05). The first time of PCEA was longer in Group oxycodone than that in Group fentanil (P<0.05). There was no significant difference in Bromage score, labor duration, delivery mode, adverse reactions, Apgar score and umbilical cord blood gas between the two groups(P>0.05). Conclusion: Levobupivacaine combined with oxycodone could accelerate the onset time of analgesia and prolong the first time of PCEA. This combination contributes steady labor duration without increasing complications during labor. It is a safe and feasible strategy for labor analgesia.
收稿日期: 2021-11-05
基金资助:陕西省自然科学基础研究计划项目（2020JM-661）
通讯作者:
宋宇龙(通讯作者),副主任医师,E-mail: simple_syl@126.com
作者简介: 赵静（1986—）,女,硕士,主治医师
引用本文:
赵静,霍奇帆,张世平,宋宇龙. 左旋布比卡因联合羟考酮在分娩镇痛中的应用[J]. 江苏大学学报:医学版, 2022, 22(1): 63-66,71.
ZHAO Jing, HUO Qifan, ZHANG Shiping, SONG Yulong.
Effect of oxycodone combined with levobupivacaine on epidural labor analgesia
. Journal of Jiangsu University(Medicine Edition), 2022, 22(1): 63-66,71.
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