纳米自组装短肽RADA16在医学中的应用研究与进展

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摘要纳米自组装短肽RADA16是一种具有独特氨基酸序列特征的生物材料，在一定条件下可自发组装形成含水量超过99%的纳米级纤维网格结构。该结构具有成分稳定、可修饰、生物相容性高和无免疫原性等特点，能模拟体内细胞外基质的孔隙度和结构，不仅为细胞提供适宜生长的微环境、促进受损组织的修复与重建，还具有良好的载药能力，近年来在细胞三维培养、组织工程、再生医学等领域得到了广泛的研究和运用。本文就纳米自组装短肽在细胞培养、药物缓释、再生医学等方面的应用作一简要综述。

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	高露瑶
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关键词 ：自组装短肽, RADA16, 细胞培养, 组织修复, 药物/蛋白缓释

收稿日期: 2020-04-22

基金资助: 国家自然科学基金资助项目（81660340）

通讯作者: 宋鸿（通讯作者），教授，硕士生导师，E-mail：hongsong@zmu.edu.cn

作者简介: 高露瑶（1992—），女，硕士研究生

引用本文:

高露瑶，敖弟书，宋鸿. 纳米自组装短肽RADA16在医学中的应用研究与进展[J]. 江苏大学学报:医学版, 2021, 31(02): 178-184.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2021/V31/I02/178

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