Abstract：Objective: To investigate the level and significance of plasma thrombospondin1(TSP1) and the platelet activating factor(PAF) in children with Kawasaki disease (KD). Methods: A total of 53 children with KD were enrolled in this study, including 32 children with coronary artery lesion(CAL) and 21 children with non coronary artery lesion (NCAL).The level of plasma TSP1 and PAF was detected by ELISA assay. Twenty normal children were collected as the control group. Results: Plasma TSP1 in acute phase of KD group increased significantly than that of the control group and the convalescence of KD group(P＜0.05)，while there was no difference between the convalescence of KD group and the control group(P>0.05).Compared with the control group, the level of plasma PAF increased obviously both in acute phase of KD group and in the convalescence of KD group(P＜0.05).The level of plasma PAF in CAL group was significantly higher than that of NCAL group(P<0.05) during the acute phase group. Conclusion: The content of plasma TSP1 and PAF were associated with inflammation of KD in acute stage. The level of plasma PAF may be a biochemical index to predict the early coronary artery lesion in KD.
王杨记， 史卫群， 王骞， 王艳， 吕进泉. 血小板反应蛋白-1和血小板活化因子在川崎病中的变化及意义[J]. 江苏大学学报:医学版, 2018, 28(04): 313-315,319.
WANG Yang-ji, SHI Wei-qun, WANG Qian, WANG Yan, Lu Jin-quan. Changes of plasma thrombospondin-1 and platelet activating factor in Kawasaki disease and their clinical significance. Journal of Jiangsu University(Medicine Edition), 2018, 28(04): 313-315,319.
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2018, Vol. 28 
