Abstract：[Abstract\]Objective: To investigate the effect of GABAergic neuron activity of entorhinal cortex in rats on sensorimotor gating and active avoidance learning. Methods: Bilaterally implanted guide cannulae into the medial entorhinal cortex(MEC) or lateral entorhinal cortex(LEC), the rats were infused with GABAA receptor agonist muscimol(1 μg/μL, 0.5 μL per hemisphere) or saline. The behavioral tests were conducted 30 min after infusion. Results: After muscimol infusion, compared with the saline infused control group, the rats in MEC group showed hyperactivity in the open filed test, more entries into the open and closed arm in the elevated plusmaze test and disruption of the prepulse inhibition at intensity of 73 dB, as well as the deficiency of learning and memory in the twoway active avoidance task. Conclusion: The entorhinal cortical neuronal activity, especial the medial entorhinal cortex area, plays important roles in the spontaneous activity, anxiety, sensorimotor gating, as well as the twoway active avoidance learning and memory of rats.
冯驰1， 李国海2， 王佳1， 姜扬1， 王玉聪1， 肖栩1，李璁1， 范尊1， 徐家丹1， 汪磊1， 张维宁1，2. 内嗅皮层γ-氨基丁酸能神经元活动对大鼠感觉运动门控及主动回避学习记忆的影响[J]. 江苏大学学报:医学版, 2017, 27(04): 282-286.
FENG Chi1, LI Guohai2, WANG Jia1, JIANG Yang1, WANG Yu-cong1， XIAO Xu1,. Effect of the GABAergic neuron activity of entorhinal cortex on sensorimotor gating and active avoidance learning in rats. Journal of Jiangsu University(Medicine Edition), 2017, 27(04): 282-286.
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2017, Vol. 27 
