[1\]Minchenko OH, Tsuchihara K, Minchenko DO, et al. Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells\[J\]. World J Gastroenterol,2014, 20(38):13705-13717.\[2\]Du JY, Wang LF, Wang Q,et al. miR26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6phosphofructo2kinase/fructose2,6bisphosphatase3 driven glycolysis in osteosarcoma cells\[J\]. Oncol Rep,2015,33(4):1890-1898.\[3\]Minchenko O, Opentanova I, Caro J. Hypoxic regulation of the 6phosphofructo-2-kinase/fructose2,6bisphosphatase gene family (PFKFB14) expression in vivo\[J\]. FEBS Lett,2003, 554(3): 264-270.\[4\]Rider MH,Bertrand L,Vertommen D,et al.6phosphofructo2kinase/fructose 2,6bisphosphatase: headtohead with a bifunctional enzyme that controls glycolysis \[J\].Biochem J,2004, 381(3): 561-579.\[5\]Minchenko O,Opentanova I,Minchenko D, et al.Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6biphosphatase4 gene via hypoxiainducible factor1alpha activation\[J\].FEBS Lett,2004,576(1/2):14-20.\[6\]Bolaos JP. Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3\[J\]. Biochem J,2013,452(3):e7-9.\[7\]Yalcin A, Telang S,Clem B,et al.Regulation of glucose metabolism by 6phosphofructo2kinase/fructose2,6bisphosphatases in cancer\[J\].Exp Mol Pathol, 2009,86(3):174-179.\[8\]Kalucka J, Missiaen R, Georgiadou M, et al. Metabolic control of the cell cycle\[J\]. Cell Cycle,2015,14(21):3379-3388.\[9\]Bock KD, Georgiadou M,Schoors S,et al.Role of PFKFB3-driven glycolysis in vessel sprouting\[J\].Cell,2013,154(3):651-663.\[10\]O′Neal J,Clem A, Reynolds L, et al. Inhibition of 6-phosphofructo-2-kinase(PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer \[J\]. Breast Cancer Res Treat,2016,160(1):29-40.\[11\]代伟伟,梁燕,刘正新. 6-磷酸果糖激酶-2/果糖-2,6-二磷酸酶在胃癌组织中的表达及其临床意义\[J\].中华消化杂志,2015,35(4):264-266.