Observation of therapeutic effects of the early combination of sertraline and flupentixol melitracen in treatment of post-stroke depression
1.Department of Neurology，the Second Affiliated Hospital of Dalian Medical University， Liaonin Dalian 116023; 2.Department of Medicine， Dalian Armed Police Hospital， Liaonin Dalian 116013， China）
Abstract：Objective: To explore clinical effectiveness of early combination sertraline and flupentixol melitracen in the treatment of post-stroke depression. Methods: Ninety patients were randomly divided into two groups，combined treatment group（treated with combination of sertrline and flupentixol melitracen for 2 weeks and then treated with sertraline for 2 weeks）and control group（with sertraline）for four weeks. All the patients were scored by Hamilton Depression Scale（HAMD）、National Institutes of Health Stroke Scale （NIHSS）and Barthel index（BI）scores before treatment and at the end of 1st，2nd，and 4th week after treatment. Results: Compared with pretreatment in both groups，the HAMD、NIHSS scores after treatment were decreased with treatment time（P <0.05），the BI index with the treatment time gradually improved and there were more significant difference（P <0.05）. There were more significant difference of HAMD、NIHSS and BI scores at the end of 1st and 2nd week between 2 groups. There were little difference at the end of 4th week（P >0.05）. The incidence of adverse effects in combined treatment group were significantly less than the control group（P <0.05）. Conclusion: The early combination of sertraline and flupentixol melitracen in the treatment of post-stroke depression works fast and has better clinical effectiveness，less adverse effects， better compliance，and is conductive to the rehabilitation of neurological function and activities of daily living recovery.
2012, Vol. 22 
