Rural college students have the characteristics of “knowing and loving agriculture” and the potential of “reviving the countryside”. They are the new force of Rural Revitalization and the important potential group of new village sages. In view of the increasing perfection of university funding system and the gradual maturity of entrepreneurship education ecosystem, as well as the feasibility of the integration of the two, this study proposes the concept and ideas of “entrepreneurial poverty alleviation” for the rural students with family economic difficulties. Compared with the traditional funding model, entrepreneurial poverty alleviation is allround, sustainable, high standing and widely beneficial, and can better realize the positive transformation from “other assistance” to “selfhelp”, from “poverty alleviation” to “talent”, and from “selfreliance” to “altruism” for those poor rural students. On this basis, the construction idea and conceptual model of entrepreneurial povertystricken ecosystem in colleges and universities are clarified, and the biological community, invisible support and energy transformation process of the system are analyzed by using the ecological theory, so as to provide the practical path for colleges and universities to guide rural students to become new village sages.