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| Research advances in risk and forewarning measures of drug-induced QT interval or QTc prolongation and torsade de pointes |
| ZHAO Yue, WANG Qian |
| Department of Pharmacy, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China |
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| Guide |
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Abstract Many commonly used medications have the potential to induce QT interval or QTc prolongation, subsequently leading to torsade de pointes (TdP) and other arhythmias, which may further deteriorate into ventricular fibrillation and even sudden cardiac death. Therefore, it is crucial to make identification, early warning and correction of risk factors in order to prevent and reduce the risk of druginduced QT interval prolongation and TdP. In recent years, clinical decision support systems and other early warning strategies have been widely employed for predicting QT interval or QTc prolongation by identifying various risk factors, and warning to the highrisk population susceptible to TdP. This article summarizes drugs and related risk factors that contribute to prolonged QT interval and TdP risk, as well as concludes the existing warning measures, aiming to offer guidance for managing patients exposed to the related risks.
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| [1] |
. [J]. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2021, 30(4): 301-304. |
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