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| Correlation between small and dense low-density lipoprotein and coronary stenosis in patients with coronary heart disease complicating type 2 diabetes |
| JIANG Shan, LIU Tongtong, LUAN Chunyu, ZHANG Peng |
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Abstract Objective To investigate the relationship between small and dense low-density lipoprotein (sd-LDL) and coronary stenosis in patients with coronary heart disease (CHD) complicating type 2 diabetes. Methods We collected the clinical data and testing results of 326 CHD patients with type 2 diabetes. Quantitative evaluation of coronary artery were performed according to coronary angiography results and by using Gensini Scoring. According to the average Gensini Score and the type of disease respectively, all the patients were grouped and made statistical analysis. Results There is no statistically significant difference in sex, history of hypertension or LDL between groups while the differences of age, glycosylated hemoglobin and sd-LDL are statistically significant (P＜0.05). The index of sd-LDL (OR=1.129，95%CI 1.075-1.221, P＜0.01) is correlated with the severity of coronary artery lesion. Its sensitivity and specificity are separately 57% and 88% in predicting the degree of coronary stenosis. Conclusion Among patients with CHD and type 2 diabetes, sd-LDL is an independent risk factor for the severity of coronary artery lesion.
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