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| Heart rate variability response to head-up tilt test in middle-aged population with different risks of atherosclerotic cardiovascular disease |
| ZHUO Minbin, ZHANG Yan, JIANG Ting, OUYANG Yu, LI Chuanchuan |
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Abstract Objective To compare the heart rate variability (HRV) response to head-up tilt test (HUTT) among middle-aged population with different risks of atherosclerotic cardiovascular disease (ACD). Methods We selected 200 subjects who had undergone HUTT. They were divided into three groups according to the risk of ACD: lowrisk group (n=65), medium-risk group (n=66) and high-risk group (n=69). Each group performed HUTT, and worn the Polar watch throughout the whole process to record HRV indexes including standardized low frequency value (LFnorm) and standardized high frequency value (HFnorm). Results From a supine resting state to an upright position during 25minute HUTT, LFnorm in the high-risk group is significantly higher than that in other two groups while LFnorm in the medium-risk group is also significantly higher than that in the low-risk group (P<0.05); HFnorm in the high-risk group is significantly lower than that in other two groups while HFnorm in the medium-risk group is significantly lower than that in the low-risk group (P<0.05). From a supine resting state to an upright position during 25minute HUTT, LFnorm either in the males or females of the three groups all tends to increase; LFnorm in the high-risk group is significantly higher than that in other two groups while LFnorm in the medium-risk group is also significantly higher than that in the low-risk group (P<0.05). HFnorm either in the males or females of the three groups shows a downward trend during the test; HFnorm in the high-risk group is significantly lower than that in other two groups while HFnorm in the medium-risk group is also significantly lower than that in the low-risk group (P<0.05). Conclusion Patients at a high risk of ACD have problems of autonomic nerve function imbalance after position change from a supine resting state to an upright position during HUTT. The imbalance is mainly manifested by strengthened modulation function of the sympathetic nerve and weakened modulation function of the vagus nerve. It implies that HRV is significantly associated with the risk of cardiovascular diseases.
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