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| Progress in application of pulsed field ablation for atrial fibrillation |
| LU Qiao, ZHANG Xianlin, WANG Hongju |
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Abstract Pulsed field ablation (PFA) as a non-thermal ablation technology is a novel method for ablating atrial fibrillation. This form of energy employs a series of highamplitude electric pulses lasting for several microseconds; when a strong pulsed electric field increases the membrane permeability, irreversible electroporation will occur, leading to the disruption of cellular homeostasis and even cell death. Since pulsed electric field has distinct non-thermal property and tissue specificity, PFA can be applied in a wider range with higher safety and shorter time to work compared with radiofrequency or cryoballoon ablation. This paper mainly introduces the principles and characteristics of PFA, and illustrates its tissue specificity and limitations in the treatment of atrial fibrillation.
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