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Level of plasma apelin and its significance in patients with different types of atrial fibrillation |
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Abstract ObjectiveTo explore the relationship among the level of plasma apelin in patients with different types of atrial fibrillation(AF), N-terminal proB-type natriuretic peptide(NT-proBNP), and left atrial diameter(LAD).MethodsEightyfive AF patients were divided into three groups, including 31 cases of paroxysmal AF(group B), 29 cases of persistent AF(group C), and 25 cases of permanent AF(group D) while 26 inpatients without AF were enrolled as control group over the same period. For the four groups, the levels of plasma apelin and NT-proBNP were detected, LAD was measured by echocardiography, and statistical analysis was performed.ResultsThe levels of plasma apelin in groups B, C, and D were significantly lower than that in group A(P<0.05 for all), and the level of group D was significantly lower than that of groups B and C(P<0.05 for all). The difference of levels of plasma apelin was not statistically significant between group B and group C(P>0.05). Compared with group A, the values of NT-proBNP in groups B, C, and D significantly increased(P<0.05 for all), and the value was the highest in group D. The difference of the value of NT-proBNP was not statistically significant between group B and group C(P>0.05). There was statistically significant difference of LAD among groups A, B, C, and D(P<0.05 for all), and the values increased gradually. Multiple correlation analysis revealed that the level of plasma apelin was negatively correlated with NTproBNP and LAD(r=-0.28,-0.32,respectively; P<0.05 for both).ConclusionThe decreased plasma apelin level was correlated with the onset and perpetuation of AF, which may be involved in atrial remodeling through antifibrosis mechanism.
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