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| Clinical analysis of changes of ECG, serum myocardial enzyme combined with EEG from 13 children with severe hand-foot-mouth disease |
| ZHANG Hui-wen |
| Department of Function, theSecond Affiliated Hospital of Nanhua University，Hengyang Hunan 421001，China |
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Abstract Objective To investigate the characteristics and clinical significance of the electrocardiogram, serum myocardial enzyme combined with electroencephalogram (EEG) from children with hand-foot-mouth disease(HFMD). Methods 13 children with severe HFMD were enrolled in the study. 12 lead ECG, serum myocardial enzymes, cardiac troponin and 16 lead EEG were performed within 2-12 h. Results Among all patients before treatment, 11 cases were with abnormal ECG, mostly sinus tachycardia, ST-T change，atrioventricular block, atrial premature contraction; 10 cases were with abnormal myocardial enzymes (aspartate aminotransferase, lactate dehydrogenase, creatine kinase and creatine kinase isoenzyme); all patients′ cardiac troponin values were higher than the normal upper limit values; 6 cases were with EEG boundaries and 7 cases were with abnormal EEG. After treatment, all patients had improvement in different degrees or were cured. Conclusion Children with severe HFMD mostly had myocardial damage and central nervous system involvement. ECG, myocardial enzymes and EEG detection should be done earlier in order to take active treatment promptly, which has important clinical application value for the observation of curative effect and prognosis evaluation.
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Received: 20 February 2013
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2013, Vol. 22 
