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| Effect of intra-coronary artery cord blood stem cell transplantation on ventricular arrhythmia |
| WEI Fang-1, LUO Han-2, LI An-Jie-1, ZHOU Yong-Gang-1, LIANG Qing-Long-1, ZHOU Song-1 |
| （1. Department of Cardiology， the People's Hospital of Guizhou， Guiyang Guizhou 550002; 2. Department of Internal Medicine， the People's Hospital of Wuwei， Wuwei Gansu 733000） |
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Abstract Objective To investigate the effect of intra-coronary artery cord blood stem cell transplantation on ventricular arrhythmia. Methods Forty coronary artery disease patients determined by coronary arteriongraphy were divided into medicinal treatment control group and stem cell transplantation experimental group. Dynamic electrocardiogram was done before and at 1， 8 weeks after transplantation. Result The arrhythmia scores at 1，8 weeks after transplantation were significantly lower than that in control group and before transplantation（P <0.05 or 0.01）. Conclusion Intra-coronary artery cord blood stem cell transplantation may reduce arrhythmia score and the occurrence of ventricular arrhythmia.
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| ［1］Tse W， Laughlim MJ. Umbilical cord blood transplantation: a new alternative option［J］. Hematology Am Soc Hematol Educ Program， 2005（1）:377-383. ［2］Menasche P， Hagege AA， Vilquin JT， et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction［J］. J Am Coll Cardiol， 2003， 41 （7）:1078-1083. ［3］Wang GY， Wu S，Pei JM， et al. Kappa-but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats［J］. Am J Physiol Heart Circ Physiol， 2001， 280（1）:H384-391. ［4］Strauer BE， Brehm M， Zeus T， et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans［J］. Circultation，2002，106（15）:1913-1918. ［5］Ma N， Stamm C， Kaminski A， et al. Human cord blood cells induce angiogenesis following myocardial infarction in NOD/ scid-mice［J］ . Cardiovasc Res， 2005， 66（1）: 45-54 .［6］ Satin J， Kehat I， Caspi O， et al. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyicytes［J］. J Physiol， 2004，559（pt2）:479-496. ［7］史力生.自体骨 髓干细胞心肌移植治疗急性心肌梗死过程中电生理特性表达及对心律失常影响的机制研究［D］.石家庄:河北医科大学，2006. |
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2012, Vol. 21 
