Abstract:ObjectiveTo study the application value of plasma B-type natriuretic peptide and C-reactive protein in cardia failure. Methods Eighty-four patients with cardia failure (observation group) and 40 health examination persons (control group) were enrolled in this study. Plasma levels of BNP and CRP were detected in 24 h after hospitalization, as well as left ventricular enddiastolic diameter (LVED) and left ventricular ejection fraction (LVEF). Results Plasma levels of BNP,CRP and LVED of the observation group were higher than those of the control group (P<0.01),and compared to cardiac function grading, it was positive correlation, while LVEF decreased (P<0.01)and it was negative correlation. It showed a significant correlation between BNP and cardiac function grading, LVEF, LVED (P<0.05), whereas CRP related to cardiac function grading only (P<0.05), There was no significant correlation between LVEF and LVED. Conclusion Both BNP and CRP may reflex the condition severity of heart failure. In clinical application, we could use the levels of BNP and CRP as an important supplement to evaluate cardiac function, but as to the specificity, BNP was better than CRP.