Abstract：This paper reviews the definition and measurement methods of QT interval prolongation, lists some clinical research evidences that QT interval prolongation leads to malignant ventricular arrhythmia and sudden cardiac death. It concludes that the mechanism of cardiovascular events and sudden death due to QT interval prolongation may be closely related to the interaction of multiple factors such as increased QT interval dispersion, uncoordinated coupling of myocardial electrical excitation and mechanical contraction, and imbalance in cardiac autonomic function regulation. It is suggested that clinicians should be highly alerted to the risk of acquired QTc prolongation caused by certain drugs in order to avoid adverse outcomes.
张兆国,赵兰婷,孔令云,张萍. QT 间期延长导致心血管事件与猝死的相关机制[J]. 实用心电学杂志, 2023, 32(6): 381-388.
ZHANG Zhaoguo, ZHAO Lanting, KONG Lingyun, ZHANG Ping. Related mechanisms of cardiovascular events and sudden death due to QT interval prolongation. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2023, 32(6): 381-388.
