摘要目的 探讨心房颤动（简称房颤）患者分别在房颤及窦性节律下，不同QT间期校正方法的应用效果。方法 从公共信息平台ECGViEW心电图数据库中筛选出同时具有房颤及窦性节律的房颤患者心电图，分别比较和分析Bazett、Fridericia、Framingham及Hodges公式对同一患者在房颤及窦性节律下的QT间期校正效果。分析经不同公式校正的QTc与心率及QT间期测量值之间的线性关系。结果 房颤患者心电图QT间期在房颤及窦性节律下比较，差异有统计学意义[(374.57±67.73) ms vs. (396.71±55.68) ms, P<0.01]。经Hodges公式校正后QTc在两种节律下差异无统计学意义，其对心率的回归直线斜率很小，且与QT间期测量值呈较好的线性关系。经临床常用的Bazett公式校正的QTc与QT间期测量值呈正线性关系。结论 常用的Bazett及Fridericia、Framingham公式在房颤节律下对心电图QT间期的校正效果欠佳。Hodges公式在房颤及窦性节律下对QT间期的校正效果接近，能较好地消除心率对QT间期的影响。Hodges公式在人群中具有普适性，是监测房颤患者QT间期延长较好的临床指标。
Abstract：Objective To explore the effect of different correction methods of QT interval in patients with atrial fibrillation (AF) separately at AF and sinus rhythms. Methods The ECGs of AF patients both with AF and sinus rhythms were selected from the public information platform ECG-ViEW database. The correction effect of Bazett, Fridericia, Framingham and Hodges formulas is compared and analyzed for the same patient separately at AF and sinus rhythms. The linear relationship between QTc corrected by different formulas and heart rate or the measured value of QT interval was analyzed. ResultsThere is a statistically significant difference in the QT interval among AF patients during AF and sinus rhythme[(374.57±67.73) ms vs. (396.71±55.68) ms, P<0.01]. The QTc corrected by Hodges formula does not vary significantly between the two rhythms. Its slope of the regression line to the heart rate is very small, and the QTc corrected by Hodges formula shows a good linear relationship with the measured value of QT interval. The QTc corrected by commonly used Bazett formula in clinical practice shows a positive linear relationship with the measured value of QT interval. Conclusion Commonly used Bazett, Fridericia and Framingham formulas lead to poor performances in correcting QT interval of ECGs during AF rhythm. The effect of Hodges formula on correcting QT interval is close separately at AF and sinus rhythms, which could greatly reduce the influence of heart rate on QT interval. Hodges formula is universal in the population, and makes a good clinical indicator for monitoring the prolongation of QT interval in AF patients.
