Abstract：The National Medical Products Administration demands that the relevant requirements for drug clinical studies initiated since July 31, 2023 follow the “E14: the clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs”. This paper introduces QT interval and QTc, non-antiarrhythmic drugs potentially leading to QT interval prolongation and even torsade de pointes, the mechanism of QT interval prolongation, predisposing factors, and other related issues. It is aimed to arouse more attention to the effects of new nonantiarrhythmic drugs on QT/QTc interval among clinicians, and to improve the safety of drug use.
米艳，罗丹，王春婷，李湘玉，莫念春，王福军. 非抗心律失常药物对QT/QTc间期影响的研究进展[J]. 实用心电学杂志, 2023, 32(4): 248-253.
MI Yan, LUO Dan, WANG Chunting, LI Xiangyu, MO Nianchun, WANG Fujun. Research advances in effects of non-antiarrhythmic drugs on QT/QTc interval. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2023, 32(4): 248-253.
