Abstract：Objective To compare the difference in the response to cardiac resynchronization therapy (CRT) between patients with true left bundle branch block (LBBB) and false LBBB. Methods Both Chinese and English databases were searched, and all the included literature was screened and identified according to the established inclusion and exclusion criteria. Relevant data including clinical manifestations, echocardiography results, treatment, and clinical outcomes were extracted for data statistics and meta-analysis. Results Ten studies are ultimately involved. Metaanalysis results show that true LBBB patients have better CRT response in the indexes including left ventricular ejection fraction (SMD 0.89, 95%CI0.64 to 1.14, P=0.000), left ventricular end diastolic dimension (SMD -0.78, 95%CI -1.35 to -0.21, P=0.008), and QRS duration (SMD -0.91, 95%CI -1.16 to -0.66, P=0.000). ConclusionDifferentiation between true and false LBBB helps to predict the prognosis of CRT, and select more appropriate population for CRT. It is instructively significant for clinical decision making.
