Abstract：As one of pulmonary arterial diseases, pulmonary arterial hypertension(PAH) is characterized by vasoconstriction, remodeling of pulmonary resistance vessel and formation of primary thrombus. Although the pathogenesis of PAH is considered to be a complex process influenced by various factors, its histopathological changes are mainly featured by the remodeling of pulmonary vessel in which the decrease of apoptosis of pulmonary artery smooth muscle cells(PASMCs) plays a crucial role. Research shows that the increase of apoptosis of PASMCs contributes to the reversion of pulmonary vessel remodeling and serious PAH; potassium channels of PASMCs are especially important for cell apoptosis and proliferation. Abundant evidences show that dysfunction of potassium channel on PASMCs is an indicator of PAH. It implies that the expression and activity of potassium channel on PASMCs significantly influence the occurrence and development of PAH.
2019, Vol. 28 
