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Numerical simulation on hemolysis induced by two-stage axial-flow blood pump during pulsating heart failure |
ZHOU Bingjing1, ZHANG Guijie1, JING Teng1, WANG Hao1, HE Zhaoming1,2 |
1. National Research Center of Pumps, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2. Department of Mechanical Engineering, Texas Tech University, Lubbock, Texas 79409, USA |
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Abstract To understand hemolysis of a blood pump in a pulsatile flow condition, a multi-scale model of the blood pump and cardiovascular circulatory system was built. This multi-scale model consists of a lumped parameter sub-model for the cardiovascular circulation and a three-dimensional distributed parameter sub-model for an axial-flow blood pump. Based on a specific two-stage axial-flow blood pump, the transient outlet pressure and flow rate through the pump were obtained by using the lumped model with Matlab simulation during a cardiac cycle under heart failure conditions. Then, according to the internal hemodynamic characteristics of the blood pump, the transient working condition was divided into a few flow rates, the hemolysis of the pump was predicted based on these flow rates in a quasi-steady manner. Finally, a time-weighted average hemolysis was calculated in one cardiac cycle. The results showed that the pump transient pressure difference-flow rate curve was a closed loop in one cardiac cycle due to the inertia of the blood pump. Besides, the hemolysis and pressure difference exhibited a similar variation trend in one cardiac cycle, the flow rate was in an opposite variation trend. In summary, the study showed that the method of multi-scale model can be used to estimate the hemolysis of a blood pump supporting patient with heart failure.
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Received: 02 June 2016
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