Higher education in China′s central and western regions is the endogenous force of the development strategy for the central and western regions. The comprehensive revitalization of higher education in the central and western regions is a powerful move to optimize the distribution of regional higher education resources, and also is a new mission and responsibility of the development of higher education in the central and western regions. To promote the comprehensive revitalization of higher education in the central and western regions, we need to form a cluster development vision of seeking common ground while shelving differences, mutual promotion and benefit, and multidimensional interaction from the perspective of symbiosis. We also need to promote the comprehensive revitalization of higher education in the central and western regions to resonate with industrial innovation at the same frequency, so as to better promote the innovation and development of higher education service industry in the central and western regions; to optimize the talent project management system, and to promote regional talent coordinated development. What′s more, to achieve the highquality revitalization of higher education in the central and western regions, we should adhere to the development concept of openness, inclusiveness and innovation, and highlight essential characteristics of endogenous innovation, social interaction and organizational coordination.