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| Toxicological study on the security of calcium titanate biological materials |
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WU Zhan-ao, XUAN Zhi-gang, SUN Min, JIANG Tao |
| （Department of Stomatology, PLA No.359 Hospital,Zhenjiang Jiangsu 212001， China) |
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Abstract [Abstract] Objective: To evaluate the biological safety of calcium titanate biological materials. Methods: Using genetic toxicity test (mouse bone marrow nuclear test) and mice hemolysis test in vitro to evaluate the biological safety and biological compatibility of the biological materials, calcium titanate,which was prepared by hydrothermal synthesis technique at 120 ℃ for 6 h with the modifier such as polyethylene glycol,sixteen alkyl three methyl bromide (CTAB), and sodium citrate. Results: The results of mouse bone marrow micronucleus test were <4‰ and hemolytic rate was <5％. Conclusion: Under this experimental condition, calcium titanate biological materials modified by the polyethylene glycol, sixteen alkyl three methyl bromide, sodium citrate and showed nothing were toxic and had no mutagenicity and hemolysis.
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Received: 10 April 2013
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2013, Vol. 23 
