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| Clinical efficacy of tacrolimus combined with small does of hormone therapy on IgA nephropathy |
| ZHANG Jun-xian, QIAN Jian-zhong |
| Department of Nephrology, Shengze Hospital of Wujiang, Suzhou Jiangsu 215228, China |
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Abstract Objective: To study the clinical efficacy and safety of tacrolimus combined with glucocorticoid on IgA nephropathy patients with moderate proteinuria. Methods: Twentyfive patients with IgA nephropathy were enrolled in the study and were randomly divided into two groups：single hormone group, 14 cases were given single glucocorticoid treatment; combined treatment group,11 cases were given tacrolimus combined with glucocorticoid treatment. The changes of 24 h urine protein, aminotransferase, serum creatinine, serum glucose, blood pressure, treatment effects, and side effects were observed and compared between two groups before and 10 d, 1 month, 2 month, 4 month, 6 month after treatment. Results: There were no significant differences between two groups with regard to side effects of treatment; and the effect of tacrolimus combined with glucocorticoid were better than taking glucocorticoid singly on IgA nephropathy. Conclusion: When tacrolimus blood concentration fluctuates at 3.76-4.35 μg/L, it takes effect more quickly on IgA nephropathy patients with moderate proteinuria and has higher clinical remission rate.
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Received: 02 September 2012
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2013, Vol. 23 
