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A 1H magnetic resonance spectroscopy study on hippocampus in patients with major depressive disorder |
| BAO He-hua1, LI Guo-hai1, LI Yi-yun1, MA Hai-bo1, WANG Dong-qing2, ZHANG Li-rong2 |
| （1.Department of Psychiatry, the Fourth Hospital Affiliated to Jiangsu University, Zhenjiang Jiangsu 212001; 2.Magnetic Resonance Imaging Center, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212002, China) |
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Abstract Objective：To explore the neurochemical characteristics and correlates of hippocampus metabolites in patients with major depressive disorder. Methods: Thirteen unmediated patients meeting the DSM-Ⅳcriteria for depression disorder(depression group), and 13 psychiatrically normal matched comparison subjects(control group) were included in the study. Proton magnetic resonance spectroscopy(1H-MRS) was used to determine the levels of N-acetylaspartate(NAA), glutamate/glutamine(Glx), choline compounds(Cho), myoinositol, and creatine(Cr) in hippocampus of all 26 subjects. Thirteen patients underwent a second 1HMRS examination after 6 weeks antidepressive treatment. The associations between metabolite levels and treatment effects were analysed. Results: NAA levels from bilateral hippocampus were significantly lower in depressive patients than in comparison subjects(for left, 0.93±0.21 vs 1.36±0.27，P=0.000; for right, 0.96±0.19 vs 1.37±0.25, P=0.000). There were no significant differences in the concentrations of Glx、Cho、myoinositol between the two groups(P＞0.05). No significant changes in the neurochemistry were observed before and after treatment with antidepressive agents(P>0.05). No correlations were found between the changes in the metabolite levels and treatment effects(P＞0.05). Conclusions: The abnormal changes of NAA, Glx, Cho, and mI metabolites in hippocampus may be implicated in the pathogenesis of depressive disorder.
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Received: 05 February 2013
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2013, Vol. 23 
