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| Clinical significance of interleukin 6, Creactive protein, neutrophil cell surface marker CD64 in the diagnostic value of neonatal infections |
| DAI Biao |
| Department of Pediatrics， the Affiliated Yixing Hospital of Jiangsu University, Yixing Jiangsu 214200， China |
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Abstract Objective: To explore clinical significance of the interleukin 6 (IL-6), Creactive protein (CRP), neutrophil cell surface marker CD64 in the diagnostic value of neonatal infections.Methods: The information of 107 cases were analyzed retrospectively; they were from Yixing people′s hospital, department of neonatology, admitted in January 2005 to December 2011. They were divided into 35 cases of sepsis group, 30 cases of nonbacterial infection, 42 cases of healthy newborns. Positive rate of IL-6 and CRP, and CD64 levels were analyzed.Results: CRPpositive rate of sepsis group、 nonbacterial infection group and the healthy controlgroup was 80%, 63.3%, 23.8% respectively.There were significant differences between the septicemia group and the healthy control group, or the nonbacterial infection group and the healthy control group（all P<0.05）. IL-6 positive rate of the three groups was 85.7%, 33.3%, 9.5% respectively , and the differences were statistically significant between the sepsis group and nonbacterial infection, or sepsis group and the healthy control group (all P<0.05). The CD64 level differences among the three groups was statistically significant (H= 77.818, P<0.01). Specificity of the combined detection IL-6+CRP+CD64 were 94.6%, and the differences were statistically significant compared to IL-6, CRP, CD64, IL-6+ CD64, CRP+CD64 (all P<0.05). Conclusion: Combined detection of IL-6, CRP and CD64 will increase the specificity of bacterial infection diagnosis, and it will provide an early diagnostic marker for clinical work.
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Received: 04 June 2012
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2012, Vol. 22 
